NADPH Oxidase Activation Is Required in Reactive Oxygen Species Generation and Cell Transformation Induced by Hexavalent Chromium

• Published in: Toxicological sciences Vol. 123; no. 2; pp. 399 - 410
• Main Authors: Wang, Xin, Son, Young-Ok, Chang, Qingshan, Sun, Lijuan, Hitron, J.Andrew, Budhraja, Amit, Zhang, Zhuo, Ke, Zunji, Chen, Fei, Luo, Jia, Shi, Xianglin
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.10.2011
• Subjects: Animals; Bronchi - drug effects; Bronchi - metabolism; Bronchi - pathology; Carcinogenicity; Carcinogens - toxicity; Cell Line; Cell Membrane - drug effects; Cell Membrane - metabolism; Cell Survival - drug effects; Cell Transformation, Neoplastic - chemically induced; Chromates - toxicity; Chromium - toxicity; Enzyme Activation; Epithelial Cells - drug effects; Epithelial Cells - metabolism; Epithelial Cells - pathology; Gene Silencing; Humans; Mice; Mice, Nude; NADPH Oxidases - biosynthesis; Neoplasm Transplantation; Neoplasms - drug therapy; Neoplasms - pathology; Oxidative Stress - drug effects; Oxidoreductases - metabolism; Phosphorylation - drug effects; Reactive Oxygen Species - metabolism; RNA, Small Interfering - genetics; Transfection; Xenograft Model Antitumor Assays; ROS generation; hexavalent chromium; carcinogenesis; NADPH oxidase

Hexavalent chromium [Cr(VI)] is a well-known human carcinogen associated with the incidence of lung cancer. Although overproduction of reactive oxygen species (ROS) has been suggested to play a major role in its carcinogenicity, the mechanisms of Cr(VI)-induced ROS production remain unclear. In this...