Granulysin-Based Lymphocyte Activation Test for Evaluating Drug Causality in Antiepileptics-Induced Severe Cutaneous Adverse Reactions

• Published in: Journal of investigative dermatology Vol. 141; no. 6; pp. 1461 - 1472.e10
• Main Authors: Chu, Mu-Tzu, Wang, Chuang-Wei, Chang, Wan-Chun, Chen, Chun-Bing, Chung, Wen-Hung, Hung, Shuen-Iu
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.06.2021
• Subjects: AED; cADR; VPA; SCAR; GZMB; MDE; DRESS; CBZ; CTL; OXC; LEV; TEN; PHT; SJS; LAT; LTG

Aromatic antiepileptic drugs (AEDs) are common causes of cutaneous adverse drug reactions, which range from morbilliform drug eruption to life-threatening severe cutaneous adverse reactions, including drug reaction with eosinophilia and systemic symptoms, Stevens‒Johnson syndrome, and toxic epiderma...