The signaling pathways and targets of traditional Chinese medicine and natural medicine in triple-negative breast cancer

• Published in: Journal of ethnopharmacology Vol. 264; no. NA; p. 113249
• Main Authors: Yang, Zimei, Zhang, Qiuhua, Yu, Linghong, Zhu, Jiayan, Cao, Yi, Gao, Xiufei
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 10.01.2021
• Subjects: adverse effects; Animals; antineoplastic activity; Antineoplastic Agents, Phytogenic - administration & dosage; Antineoplastic Agents, Phytogenic - metabolism; beta catenin; Biological Products - administration & dosage; Biological Products - metabolism; breast neoplasms; Cell Line, Tumor; Drug Delivery Systems - methods; Drug Delivery Systems - trends; drug development; Female; genes; herbal medicines; Humans; mechanism of action; Medicine, Chinese Traditional - methods; Medicine, Chinese Traditional - trends; metastasis; mitogen-activated protein kinase; Natural medicine; Oriental traditional medicine; phosphatidylinositol 3-kinase; prognosis; protein synthesis; signal transduction; Signal Transduction - drug effects; Signal Transduction - physiology; Signaling pathway; Target; Traditional Chinese medicine; Triple Negative Breast Neoplasms - drug therapy; Triple Negative Breast Neoplasms - genetics; Triple Negative Breast Neoplasms - metabolism; Triple-negative breast cancer; Traditional Chinese medicine; Natural medicine; Target; Signaling pathway; Triple-negative breast cancer

Triple-negative breast cancer (TNBC) has a poorer prognosis than other subtypes due to its strong invasion and higher risk of distant metastasis. Traditional Chinese medicine (TCM) and natural medicine have the unique advantages of multitargets and small side-effects and may be used as long-term com...