DNA methylation alterations exhibit intraindividual stability and interindividual heterogeneity in prostate cancer metastases

• Published in: Science translational medicine Vol. 5; no. 169; p. 169ra10
• Main Authors: Aryee, Martin J, Liu, Wennuan, Engelmann, Julia C, Nuhn, Philipp, Gurel, Meltem, Haffner, Michael C, Esopi, David, Irizarry, Rafael A, Getzenberg, Robert H, Nelson, William G, Luo, Jun, Xu, Jianfeng, Isaacs, William B, Bova, G Steven, Yegnasubramanian, Srinivasan
• Format: Journal Article
• Language: English
• Published: United States 23.01.2013
• Subjects: Alleles; Clone Cells; DNA Methylation - genetics; DNA-Binding Proteins - chemistry; DNA-Binding Proteins - genetics; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Genetic Heterogeneity; Genomics; Humans; Male; Neoplasm Metastasis; Polymorphism, Single Nucleotide - genetics; Prostatic Neoplasms - genetics; Prostatic Neoplasms - pathology; Protein Structure, Tertiary

Human cancers almost ubiquitously harbor epigenetic alterations. Although such alterations in epigenetic marks, including DNA methylation, are potentially heritable, they can also be dynamically altered. Given this potential for plasticity, the degree to which epigenetic changes can be subject to se...