Sildenafil induces browning of subcutaneous white adipose tissue in overweight adults - Li, Shuguang; Li, Yixiang; Xiang, Lin; Dong, Jing; Liu, Min; Xiang, Guangda (Metabolism, clinical and experimental, 2018)
Keywords: Adipocytes - drug effects; Adipocytes - metabolism; Adipose Tissue, Brown - drug effects; Adipose Tissue, Brown - metabolism; Adipose Tissue, White - drug effects; Adipose Tissue, White - metabolism; Adult; Animals; Browning of white adipose; Catecholamines - metabolism; Cell Adhesion Molecules - metabolism; Cyclic GMP-Dependent Protein Kinase Type I - metabolism; Double-Blind Method; Human adult; Humans; Male; Mice; Mice, Inbred C57BL; Microfilament Proteins - metabolism; Mitochondria - drug effects; Mitochondria - metabolism; Mitochondrial Proteins - metabolism; Obesity - drug therapy; Obesity - metabolism; Overweight - drug therapy; Overweight - metabolism; Phosphodiesterase type-5 inhibitor; Phosphoproteins - metabolism; Signal Transduction - drug effects; Sildenafil Citrate - therapeutic use; Subcutaneous Fat - drug effects; Subcutaneous Fat - metabolism; Uncoupling Protein 1 - metabolism; Vasodilator-Stimulated Phosphoprotein; Young Adult; Human adult; sWAT; fT3; LDL-C; cGMP; FBG; WAT; HDL-C; MYDGF; Browning of white adipose; PRDM16; mTOR; FMD; LC3; FGF21; VASP; PDE5i; DIO2; PGC-1α; UCP-1; Phosphodiesterase type-5 inhibitor; IL-6; TC; S6K1; iWAT; TNF-α; ADRB3; BAT; RMR