Nanocell COVID-19 vaccine triggers a novel immune response pathway producing high-affinity antibodies which neutralize all variants of concern

• Published in: Frontiers in immunology Vol. 13; p. 1038562
• Main Authors: Gao, Steven Y, Amaro-Mugridge, Nancy B, Madrid-Weiss, Jocelyn, Petkovic, Nikolina, Vanegas, Natasha, Visvanathan, Kumar, Williams, Bryan R G, MacDiarmid, Jennifer A, Brahmbhatt, Himanshu
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 27.01.2023
• Subjects: Animals; Antigen Presentation; COVID-19; COVID-19 Vaccines; Humans; Immunology; iNKT activation; Leukocytes, Mononuclear; memory B cell; memory T cell; Mice; nanocell vaccine; SARS-CoV-2; variants of concern; COVID-19; iNKT activation; memory T cell; nanocell vaccine; variants of concern; memory B cell

Most current anti-viral vaccines elicit a humoral and cellular immune response the pathway of phagocytic cell mediated viral antigen presentation to B and T cell surface receptors. However, this pathway results in reduced ability to neutralize S-protein Receptor Binding Domains (RBDs) from several V...