N-3 PUFA increase bioavailability and function of endothelial progenitor cells

• Published in: Food & function Vol. 5; no. 8; pp. 1881 - 1890
• Main Authors: Spigoni, Valentina, Lombardi, Carlo, Cito, Monia, Picconi, Angela, Ridolfi, Valentina, Andreoli, Roberta, Anelli, Nadia, Gnudi, Luigi, Goldoni, Matteo, Zavaroni, Ivana, Raddino, Riccardo, Cas, Alessandra Dei
• Format: Journal Article
• Language: English
• Published: England 01.08.2014
• Subjects: Adult; Animals; Apoptosis - drug effects; bioavailability; Brackish; Cell Proliferation - drug effects; Cell Survival - drug effects; Chemokine CCL2 - genetics; Chemokine CCL2 - metabolism; diet; Docosahexaenoic Acids - blood; Eicosapentaenoic Acid - blood; Endothelial Progenitor Cells - drug effects; Endothelial Progenitor Cells - metabolism; Female; Fishes; flow cytometry; Humans; intercellular adhesion molecule-1; Intercellular Adhesion Molecule-1 - genetics; Intercellular Adhesion Molecule-1 - metabolism; interleukin-8; Interleukin-8 - genetics; Interleukin-8 - metabolism; Leukocytes, Mononuclear - metabolism; mackerel; Male; Marine; mononuclear leukocytes; NF-kappa B - genetics; NF-kappa B - metabolism; omega-3 fatty acids; polyunsaturated fatty acids; sardines; Sardinops; Scomber; Seafood; stem cells; surface antigens; tumor necrosis factor-alpha; Tumor Necrosis Factor-alpha - metabolism; Vascular Cell Adhesion Molecule-1 - genetics; Vascular Cell Adhesion Molecule-1 - metabolism; vascular cell adhesion molecules; vascular endothelial growth factor receptor-2; Vascular Endothelial Growth Factor Receptor-2 - metabolism; viability

Recent data suggest that n-3 PUFA exert beneficial effects on endothelial progenitor cell (EPC) biology. We sought to investigate whether these effects might be mediated by enhanced EPC in vitro function and/or in vivo bioavailability. CACs and late-outgrowth EPCs were isolated from peripheral blood...