Exploring metabolic pathways that contribute to the stem cell phenotype

• Published in: Biochimica et biophysica acta Vol. 1830; no. 2; pp. 2361 - 2369
• Main Authors: Vacanti, Nathaniel M., Metallo, Christian M.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.02.2013
• Subjects: adult stem cells; aerobiosis; biochemical pathways; cell proliferation; cells; Cellular redox; energy; enzymes; Glycolysis; homeostasis; Humans; Metabolic flux; nutrients; Oxidation-Reduction; Phenotype; Pluripotent cell; Stem cell; Stem Cells - cytology; Stem Cells - metabolism; transcription factors; HK; SHMTs; GLN; OXPHOS; mESCs; IDH; R5P; GLS; HIFs; GLU; MSCs; MalCoA; PFK; FBP; GLY; SDH; HBP; mTOR; FAs; GlcNAc; PKM1; CYS; ESCs; SUC; F6P; MEFs; G6PD; 6PGL; Cellular redox; 2PG; DHAP; PGD; 6PG; CIT; OAC; 2HG; ACLY; TCA; PGK; Pluripotent cell; GAP; ROS; BPG; MAL; TKT; GAPDH; NADPH; αKG; SER; FH; PGAM; Stem cell; ENO; γ-GLU-CYS; PHI; iPSCs; LDH; PPP; Metabolic flux; NADH; THF; PDH; PDK; MEETHF; UCP2; Δm; NADP; GSH; WT; 8-OHdG; FUM; G6P; GSSG; PKM2; GSS; GSR; ALDO; PYR; 3PG; LAC; NAD; AcCoA; ALDH; NAC; GCLC; Gluc; TALDO; PSCs; Glycolysis; ACO1; PEP; ACO2; ICT; GCLM; hESCs; ATP

Stem cells must negotiate their surrounding nutritional and signaling environment and respond accordingly to perform various functions. Metabolic pathways enable these responses, providing energy and biosynthetic precursors for cell proliferation, motility, and other functions. As a result, metaboli...