New strategy for renal fibrosis: Targeting Smad3 proteins for ubiquitination and degradation - Wang, Xin; Feng, Shaozhen; Fan, Jinjin; Li, Xiaoyan; Wen, Qiong; Luo, Ning (Biochemical pharmacology, 2016)
Keywords: Amino Acid Motifs; Benzofurans - chemistry; Benzofurans - metabolism; Benzofurans - therapeutic use; Binding Sites; Cell Line, Tumor; Computer-aided drug design; Drug Design; Fibrosis; Humans; Hypoxia-Inducible Factor 1, alpha Subunit - chemistry; Hypoxia-Inducible Factor 1, alpha Subunit - metabolism; Hypoxia-Inducible Factor 1, alpha Subunit - therapeutic use; Kidney - drug effects; Kidney - metabolism; Kidney - pathology; Ligands; Models, Molecular; Molecular Docking Simulation; Molecular Targeted Therapy; Peptide Fragments - chemistry; Peptide Fragments - metabolism; Peptide Fragments - therapeutic use; Protein Interaction Domains and Motifs; Proteolysis - drug effects; Proteolysis targeting chimeric molecules; Pyridines - chemistry; Pyridines - metabolism; Pyridines - therapeutic use; Recombinant Fusion Proteins - chemistry; Recombinant Fusion Proteins - metabolism; Recombinant Fusion Proteins - therapeutic use; Renal Insufficiency, Chronic - drug therapy; Renal Insufficiency, Chronic - metabolism; Renal Insufficiency, Chronic - pathology; Smad3 Protein - antagonists & inhibitors; Smad3 Protein - chemistry; Smad3 Protein - metabolism; Small Molecule Libraries; Surface Plasmon Resonance; Ubiquitin-Protein Ligases - chemistry; Ubiquitin-Protein Ligases - metabolism; Ubiquitination; Ubiquitination - drug effects; Computer-aided drug design; Ubiquitination; Proteolysis targeting chimeric molecules; Fibrosis