Synthesis and properties of fully-modified 4′-selenoRNA, an endonuclease-resistant RNA analog

• Published in: Bioorganic & medicinal chemistry Vol. 76; p. 117093
• Main Authors: Ota, Masashi, Takahashi, Hiromi, Nogi, Yuhei, Kagotani, Yuma, Saito-Tarashima, Noriko, Kondo, Jiro, Minakawa, Noriaki
• Format: Journal Article
• Language: English
• Published: OXFORD Elsevier Ltd 15.12.2022; Elsevier
• Subjects: 4′-selenoribonucleoside; 4′-selenoRNA; Biochemistry & Molecular Biology; Chemistry; Chemistry, Medicinal; Chemistry, Organic; Endonucleases; Life Sciences & Biomedicine; modified RNA; Nuclease resistance; Pharmacology & Pharmacy; Physical Sciences; RNA; Science & Technology; siRNA; X-ray analysis; 4′-selenoRNA; modified RNA; Nuclease resistance; X-ray analysis; siRNA; 4′-selenoribonucleoside; 4?-selenoRNA; CONTACTS; PRACTICAL SYNTHESIS; NUCLEOSIDES; STABILITY; 2'-HYDROXYL; HYBRIDIZATION; 4?-selenoribonucleoside; 4'-THIORNA; 1ST SYNTHESIS; DNA; 4'-THIORIBONUCLEOSIDES

[Display omitted] A large number of chemically modified oligonucleotides (ONs) have been developed for RNA-based technologies. In most modified RNAs, the characteristic 2′-hydroxyl (2′-OH) groups are removed to enhance both nuclease resistance and hybridization ability. However, the importance of th...