Di-n-butyl phthalate exposure negatively influences structural and functional neuroplasticity via Rho-GTPase signaling pathways

• Published in: Food and chemical toxicology Vol. 105; pp. 34 - 43
• Main Authors: Ding, Yuemin, Lu, Lingchao, Xuan, Chengkai, Han, Jiajv, Ye, Shumin, Cao, Tingting, Chen, Weibo, Li, Aiqing, Zhang, Xiong
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.07.2017
• Subjects: Animals; Cell Movement - drug effects; Di-n-butyl phthalate (DBP); Dibutyl Phthalate - pharmacology; Female; Mice; Mice, Inbred ICR; Neuronal Plasticity - drug effects; Neurons - cytology; Neurons - drug effects; Neurons - metabolism; Neuroplasticity; rho GTP-Binding Proteins - genetics; rho GTP-Binding Proteins - metabolism; Rho-GTPase; Signal Transduction - drug effects; Neuroplasticity; MWM; ROCK; DMSO; GST; LTP; PVDF; ECL; DIV; BBP; DMEM; SDS-PAGE; Di-n-butyl phthalate (DBP); CREB; DBP; DiBP; ANOVA; DEHP; FBS; LIMK; PAEs; PAK; GAPDH; Rho-GTPase

Di-n-butyl phthalate (DBP) has been reported to cause disruptions in hippocampal plasticity, but its specific mechanism has not yet been ascertained. In this research, a mouse model of chronic DBP exposure was generated by intragastric administration of DBP (10, 50, or 250°mg/kg/d) for 5 weeks. Chro...