Noise-induced changes of neuronal spontaneous activity in mice inferior colliculus brain slices

• Published in: Neuroscience letters Vol. 368; no. 3; pp. 297 - 302
• Main Authors: Basta, Dietmar, Ernest, Arne
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 30.09.2004; Elsevier
• Subjects: Acoustic Stimulation - methods; Animals; Auditory midbrain; Biological and medical sciences; Brain slice; Ear and associated structures. Auditory pathways and centers. Hearing. Vocal organ. Phonation. Sound production. Echolocation; Evoked Potentials, Auditory, Brain Stem - physiology; Female; Fundamental and applied biological sciences. Psychology; In Vitro Techniques; Inferior Colliculi - physiology; Male; Mice; Neurons - physiology; Noise; Noise - adverse effects; Spontaneous activity; Vertebrates: nervous system and sense organs; Brain slice; Auditory midbrain; Noise; Spontaneous activity; Rodentia; Central nervous system; Midbrain; Encephalon; Vertebrata; Mammalia; Colliculus inferior; Mouse; Animal; Auditory pathway

The inferior colliculus (IC) in vivo is reportedly subject to a noise-induced decrease of GABA-related inhibitory synaptic transmission accompanied by an amplitude increase of auditory evoked responses, a widening of tuning curves and a higher neuronal discharge rate at suprathreshold levels. Howeve...