Post-translational regulation of sphingosine kinases

• Published in: Biochimica et biophysica acta Vol. 1831; no. 1; pp. 147 - 156
• Main Authors: Chan, Huasheng, Pitson, Stuart M.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.01.2013
• Subjects: angiogenesis; Animals; apoptosis; calcium; Cancer; cell movement; dysregulation; Gene Expression Regulation; homeostasis; Humans; immune response; Isoenzymes - genetics; Isoenzymes - metabolism; Lipid; Lysophospholipids - metabolism; Phosphotransferases (Alcohol Group Acceptor) - genetics; Phosphotransferases (Alcohol Group Acceptor) - metabolism; phosphotransferases (kinases); Post-translational regulation; Protein Processing, Post-Translational - genetics; regulations; Sphingolipids - metabolism; Sphingosine; Sphingosine - analogs & derivatives; Sphingosine - metabolism; Sphingosine 1-phosphate; Sphingosine kinase; PS; PTK; CIB1; HDAC1/2; Sphingosine 1-phosphate; SKi; PI3P; S1P; Post-translational regulation; Sphingosine; SK; eEF1A; SKIP; Sphingosine kinase; IL; PTI-1; PP2A; DMS; ER; Lipid; PA; TRAF-2; ERK1/2; TNF-α; BVDV; Cancer

Sphingosine kinases (SKs) catalyse the conversion of sphingosine to sphingosine 1-phosphate (S1P), a signalling lipid that is involved in a plethora of cellular processes including proliferation, apoptosis, calcium homeostasis, angiogenesis, vascular and neuronal maturation, cell migration and immun...