Post-translational regulation of sphingosine kinases

Sphingosine kinases (SKs) catalyse the conversion of sphingosine to sphingosine 1-phosphate (S1P), a signalling lipid that is involved in a plethora of cellular processes including proliferation, apoptosis, calcium homeostasis, angiogenesis, vascular and neuronal maturation, cell migration and immun...

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Published in	Biochimica et biophysica acta Vol. 1831; no. 1; pp. 147 - 156
Main Authors	Chan, Huasheng, Pitson, Stuart M.
Format	Journal Article
Language	English
Published	Netherlands Elsevier B.V 01.01.2013
Subjects	angiogenesis Animals apoptosis calcium Cancer cell movement dysregulation Gene Expression Regulation homeostasis Humans immune response Isoenzymes - genetics Isoenzymes - metabolism Lipid Lysophospholipids - metabolism Phosphotransferases (Alcohol Group Acceptor) - genetics Phosphotransferases (Alcohol Group Acceptor) - metabolism phosphotransferases (kinases) Post-translational regulation Protein Processing, Post-Translational - genetics regulations Sphingolipids - metabolism Sphingosine Sphingosine - analogs & derivatives Sphingosine - metabolism Sphingosine 1-phosphate Sphingosine kinase PS PTK CIB1 HDAC1/2 Sphingosine 1-phosphate SKi PI3P S1P Post-translational regulation Sphingosine SK eEF1A SKIP Sphingosine kinase IL PTI-1 PP2A DMS ER Lipid PA TRAF-2 ERK1/2 TNF-α BVDV Cancer
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Abstract	Sphingosine kinases (SKs) catalyse the conversion of sphingosine to sphingosine 1-phosphate (S1P), a signalling lipid that is involved in a plethora of cellular processes including proliferation, apoptosis, calcium homeostasis, angiogenesis, vascular and neuronal maturation, cell migration and immune responses. Over the last few years, it has become clear that SKs are subject to various forms of post-translational regulation which play important roles in the function of these enzymes. Moreover, dysregulation of SKs has been implicated in many pathological conditions, such as cancer. Here we review the various mechanisms of post-translational regulation of the SKs with the view that such knowledge may lead to the development of therapeutic strategies to modulate the activities of these enzymes in the treatment of cancer and a range of other conditions. This article is part of a Special Issue entitled Advances in Lysophospholipid Research. ► SKs are critical regulators of cellular signalling. ► Post-translational regulation of SKs plays an important role in their function. ► SKs are regulated by phosphorylation and interaction with proteins and lipids. ► Subcellular localisation of SKs is important for their signalling function. ► Degradation of SKs may serve as a further regulation of these enzymes.
AbstractList	Sphingosine kinases (SKs) catalyse the conversion of sphingosine to sphingosine 1-phosphate (S1P), a signalling lipid that is involved in a plethora of cellular processes including proliferation, apoptosis, calcium homeostasis, angiogenesis, vascular and neuronal maturation, cell migration and immune responses. Over the last few years, it has become clear that SKs are subject to various forms of post-translational regulation which play important roles in the function of these enzymes. Moreover, dysregulation of SKs has been implicated in many pathological conditions, such as cancer. Here we review the various mechanisms of post-translational regulation of the SKs with the view that such knowledge may lead to the development of therapeutic strategies to modulate the activities of these enzymes in the treatment of cancer and a range of other conditions. This article is part of a Special Issue entitled Advances in Lysophospholipid Research. Sphingosine kinases (SKs) catalyse the conversion of sphingosine to sphingosine 1-phosphate (S1P), a signalling lipid that is involved in a plethora of cellular processes including proliferation, apoptosis, calcium homeostasis, angiogenesis, vascular and neuronal maturation, cell migration and immune responses. Over the last few years, it has become clear that SKs are subject to various forms of post-translational regulation which play important roles in the function of these enzymes. Moreover, dysregulation of SKs has been implicated in many pathological conditions, such as cancer. Here we review the various mechanisms of post-translational regulation of the SKs with the view that such knowledge may lead to the development of therapeutic strategies to modulate the activities of these enzymes in the treatment of cancer and a range of other conditions. This article is part of a Special Issue entitled Advances in Lysophospholipid Research.Sphingosine kinases (SKs) catalyse the conversion of sphingosine to sphingosine 1-phosphate (S1P), a signalling lipid that is involved in a plethora of cellular processes including proliferation, apoptosis, calcium homeostasis, angiogenesis, vascular and neuronal maturation, cell migration and immune responses. Over the last few years, it has become clear that SKs are subject to various forms of post-translational regulation which play important roles in the function of these enzymes. Moreover, dysregulation of SKs has been implicated in many pathological conditions, such as cancer. Here we review the various mechanisms of post-translational regulation of the SKs with the view that such knowledge may lead to the development of therapeutic strategies to modulate the activities of these enzymes in the treatment of cancer and a range of other conditions. This article is part of a Special Issue entitled Advances in Lysophospholipid Research. Sphingosine kinases (SKs) catalyse the conversion of sphingosine to sphingosine 1-phosphate (S1P), a signalling lipid that is involved in a plethora of cellular processes including proliferation, apoptosis, calcium homeostasis, angiogenesis, vascular and neuronal maturation, cell migration and immune responses. Over the last few years, it has become clear that SKs are subject to various forms of post-translational regulation which play important roles in the function of these enzymes. Moreover, dysregulation of SKs has been implicated in many pathological conditions, such as cancer. Here we review the various mechanisms of post-translational regulation of the SKs with the view that such knowledge may lead to the development of therapeutic strategies to modulate the activities of these enzymes in the treatment of cancer and a range of other conditions. This article is part of a Special Issue entitled Advances in Lysophospholipid Research. ► SKs are critical regulators of cellular signalling. ► Post-translational regulation of SKs plays an important role in their function. ► SKs are regulated by phosphorylation and interaction with proteins and lipids. ► Subcellular localisation of SKs is important for their signalling function. ► Degradation of SKs may serve as a further regulation of these enzymes.
Author	Chan, Huasheng Pitson, Stuart M.
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BackLink	https://www.ncbi.nlm.nih.gov/pubmed/22801036$$D View this record in MEDLINE/PubMed
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Keywords	PS PTK CIB1 HDAC1/2 Sphingosine 1-phosphate SKi PI3P S1P Post-translational regulation Sphingosine SK eEF1A SKIP Sphingosine kinase IL PTI-1 PP2A DMS ER Lipid PA TRAF-2 ERK1/2 TNF-α BVDV Cancer
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Snippet	Sphingosine kinases (SKs) catalyse the conversion of sphingosine to sphingosine 1-phosphate (S1P), a signalling lipid that is involved in a plethora of...
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SubjectTerms	angiogenesis Animals apoptosis calcium Cancer cell movement dysregulation Gene Expression Regulation homeostasis Humans immune response Isoenzymes - genetics Isoenzymes - metabolism Lipid Lysophospholipids - metabolism Phosphotransferases (Alcohol Group Acceptor) - genetics Phosphotransferases (Alcohol Group Acceptor) - metabolism phosphotransferases (kinases) Post-translational regulation Protein Processing, Post-Translational - genetics regulations Sphingolipids - metabolism Sphingosine Sphingosine - analogs & derivatives Sphingosine - metabolism Sphingosine 1-phosphate Sphingosine kinase
Title	Post-translational regulation of sphingosine kinases
URI	https://dx.doi.org/10.1016/j.bbalip.2012.07.005 https://www.ncbi.nlm.nih.gov/pubmed/22801036 https://www.proquest.com/docview/1141541246 https://www.proquest.com/docview/2000098195
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