Ginseng polysaccharides enhanced ginsenoside Rb1 and microbial metabolites exposure through enhancing intestinal absorption and affecting gut microbial metabolism

• Published in: Journal of ethnopharmacology Vol. 216; no. NA; pp. 47 - 56
• Main Authors: Shen, Hong, Gao, Xue-Jiao, Li, Ting, Jing, Wang-Hui, Han, Bei-Lei, Jia, Yu-Meng, Hu, Nan, Yan, Zhi-Xiang, Li, Song-Lin, Yan, Ru
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 24.04.2018
• Subjects: absorption; bacteria; beta-glucosidase; blood sampling; cell growth; cold stress; colitis; dextran; digestive system; drinking water; dysbiosis; enzyme activity; epithelium; feces; ginsenosides; human cell lines; intestinal absorption; intestinal microorganisms; metabolites; oral administration; Oriental traditional medicine; p-nitrophenol; Panax; pharmacokinetics; rats; reverse transcriptase polymerase chain reaction; synergism; Rb1; BHI; IL; DSS; PPD; DMSO; CK; GP; MTT; DAI; MPO; UC; AUC; PNPG; LC-MS/MS; DMEM; TCMs; TNF-α; FBS

Polysaccharides and small molecules commonly co-exist in decoctions of traditional Chinese medicines (TCMs). Our previous study outlined that ginseng polysaccharides (GP) could interact with co-existing ginsenosides to produce synergistic effect in an over-fatigue and acute cold stress model via gut...