β-Caryophyllene causes regression of endometrial implants in a rat model of endometriosis without affecting fertility

• Published in: European journal of pharmacology Vol. 702; no. 1-3; pp. 12 - 19
• Main Authors: Abbas, Manal A., Taha, Mutasem O., Zihlif, Malek A., Disi, Ahmad M.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 28.02.2013
• Subjects: adults; Angiogenesis Inhibitors - pharmacology; Angiogenesis Inhibitors - therapeutic use; animal models; Animals; anti-inflammatory activity; anti-inflammatory agents; Anti-Inflammatory Agents - pharmacology; Anti-Inflammatory Agents - therapeutic use; Aorta, Thoracic - drug effects; Aorta, Thoracic - physiology; Aortic ring assay; apoptosis; beta-caryophyllene; blood vessels; corpus luteum; Disease Models, Animal; Endometriosis; Endometriosis - drug therapy; Endometriosis - pathology; endometrium; Endometrium - drug effects; Endometrium - pathology; endothelial cells; eosinophils; Female; Fertility - drug effects; In Vitro Techniques; Male; mast cells; Neovascularization, Physiologic - drug effects; patients; pregnancy outcome; Prostheses and Implants; Rat surgical model; Rats; Reproduction - drug effects; Sesquiterpenes - pharmacology; Sesquiterpenes - therapeutic use; therapeutics; Ultrastructure; viability; β-Caryophyllene; β-Caryophyllene; Rat surgical model; Endometriosis; Aortic ring assay; Ultrastructure

Many studies have shown that anti-inflammatory agents are effective in the treatment of endometriosis. β-Caryophyllene exerted a potent anti-inflammatory effect in vivo. However, its effect on endometriosis has not been investigated. This study aims at investigating the effect of β-caryophyllene on...