Protective role of quercetin against lead-induced inflammatory response in rat kidney through the ROS-mediated MAPKs and NF-κB pathway - Liu, Chan-Min; Sun, Yun-Zhi; Sun, Jian-Mei; Ma, Jie-Qiong; Cheng, Chao (Biochimica et biophysica acta, 2012)
Keywords: Animals; antioxidant activity; Antioxidants - pharmacology; blood serum; Cells, Cultured; creatinine; Cytoprotection - drug effects; Cytoprotection - immunology; diet; dose response; drinking water; drugs; Extracellular Signal-Regulated MAP Kinases - metabolism; Extracellular Signal-Regulated MAP Kinases - physiology; histopathology; inflammation; Inflammation Mediators - metabolism; interleukin-1beta; interleukin-6; kidneys; lead; lead acetate; Lead Poisoning - complications; Lead Poisoning - immunology; Lead Poisoning - metabolism; Lead Poisoning - pathology; Male; MAPK; mitogen-activated protein kinase; Models, Biological; Nephritis - chemically induced; Nephritis - metabolism; Nephritis - pathology; Nephritis - prevention & control; nephroprotective effect; nephrotoxicity; NF-kappa B - metabolism; NF-kappa B - physiology; NF-κB; Oxidative stress; prostaglandin synthase; Quercetin; Quercetin - pharmacology; Rats; Rats, Wistar; reactive oxygen species; Reactive Oxygen Species - metabolism; Reactive Oxygen Species - pharmacology; Renal inflammation; risk factors; signal transduction; Signal Transduction - drug effects; thiobarbituric acid-reactive substances; transcription factor NF-kappa B; tumor necrosis factor-alpha; urea; uric acid; Oxidative stress; COX-2; QU; JNK; TBARS; IL-1β; MAPK; IL-6; NF-κB; Pb; Renal inflammation; TNF-α; ROS; Quercetin; ERK; MAPKs