Altered Rbfox1-Vamp1 pathway and prefrontal cortical dysfunction in schizophrenia

• Published in: Molecular psychiatry Vol. 29; no. 5; pp. 1382 - 1391
• Main Authors: Chung, Youjin, Dienel, Samuel J., Belch, Matthew J., Fish, Kenneth N., Ermentrout, G. Bard, Lewis, David A., Chung, Daniel W.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.05.2024; Nature Publishing Group
• Subjects: 13/51; 14/19; 38/32; 631/378; 692/699/476/1799; Adult; Alternative splicing; Behavioral Sciences; Biological Psychology; Computational neuroscience; Female; Gamma Rhythm - physiology; gamma-Aminobutyric Acid - metabolism; Humans; Hybridization; Immunohistochemistry; Interneurons; Interneurons - metabolism; Isoforms; Male; Medicine; Medicine & Public Health; Membrane proteins; Mental disorders; Middle Aged; Neurosciences; Oscillations; Parvalbumin; Parvalbumins - metabolism; Pharmacotherapy; Prefrontal cortex; Prefrontal Cortex - metabolism; Proteins; Psychiatry; Pyramidal cells; RNA Splicing Factors - genetics; RNA Splicing Factors - metabolism; RNA, Messenger - metabolism; Schizophrenia; Schizophrenia - genetics; Schizophrenia - metabolism; Schizophrenia - physiopathology; Signal Transduction - physiology; Vesicle-Associated Membrane Protein 1 - genetics; Vesicle-Associated Membrane Protein 1 - metabolism; γ-Aminobutyric acid

Deficient gamma oscillations in prefrontal cortex (PFC) of individuals with schizophrenia appear to involve impaired inhibitory drive from parvalbumin-expressing interneurons (PVIs). Inhibitory drive from PVIs is regulated, in part, by RNA binding fox-1 homolog 1 (Rbfox1). Rbfox1 is spliced into nuc...