[4+2]-Cycloaddition to 5-Methylidene-Hydantoins and 5-Methylidene-2-Thiohydantoins in the Synthesis of Spiro-2-Chalcogenimidazolones

• Published in: International journal of molecular sciences Vol. 24; no. 5; p. 5037
• Main Authors: Shybanov, Dmitry E., Kukushkin, Maxim E., Hrytseniuk, Yanislav S., Grishin, Yuri K., Roznyatovsky, Vitaly A., Tafeenko, Viktor A., Skvortsov, Dmitry A., Zyk, Nikolai V., Beloglazkina, Elena K.
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.03.2023; MDPI
• Subjects: Biological activity; Cycloaddition Reaction; Cyclopentanes; Cytotoxicity; Escherichia coli; HEK293 Cells; Humans; Hydantoins; Hydrogen Peroxide; Olefins; Thiohydantoins; antibacterial activity; 2-thiohydantoins; spiro-compounds; [4+2]-cycloaddition; Diels–Alder reaction; cytotoxicity; hydantoins

Novel hydantion and thiohydantoin-based spiro-compounds were prepared via theDiels–Alder reactions between 5-methylidene-hydantoins or 5-methylidene-2-thiohydantoins and 1,3-dienes (cyclopentadiene, cyclohexadiene, 2,3-dimethylbutadiene, isoprene). It was shown that the cycloaddition reactions proce...