Pharmacokinetics effects of chuanxiong rhizoma on warfarin in pseudo germ-free rats

• Published in: Frontiers in pharmacology Vol. 13; p. 1022567
• Main Authors: Li, Haigang, Zhou, Yi, Liao, Luanfeng, Tan, Hongyi, Li, Yejun, Li, Zibo, Zhou, Bilan, Bao, Meihua, He, Binsheng
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 05.01.2023
• Subjects: chuanxiong; gut microbiota; MCAO (middle cerebral artery occlusion); pharmacokinetics; Pharmacology; UPLC-MS/MS; warfarin; pharmacokinetics; chuanxiong; UPLC-MS/MS; gut microbiota; MCAO (middle cerebral artery occlusion); warfarin

In China, warfarin is usually prescribed with Chuanxiong Rhizoma for treating thromboembolism diseases. However, the reason for their combination is still being determined. The present study explored the pharmacokinetics interactions of warfarin, Chuanxiong Rhizoma, and gut microbiota in the rat mod...