MicroRNAs: Key regulators of endothelial progenitor cell functions

Development of cardiovascular diseases mobilises endothelial progenitor cells (EPCs) from the bone marrow to participate in vascular repair and formation of new blood vessels under both pathological and physiological conditions. Therefore, EPCs show great potential for therapeutic applications; howe...

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Published in	Clinica chimica acta Vol. 448; pp. 65 - 73
Main Authors	Qu, Kai, Wang, Zuo, Lin, Xiao-long, Zhang, Kai, He, Xing-lan, Zhang, Hai
Format	Journal Article
Language	English
Published	Netherlands Elsevier B.V 25.08.2015
Subjects	Angiogenesis Animals Cardiovascular diseases Endothelial progenitor cells Endothelial Progenitor Cells - cytology Endothelial Progenitor Cells - metabolism Humans MicroRNA MicroRNAs - metabolism Angiogenesis MicroRNA Cardiovascular diseases Endothelial progenitor cells
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Abstract	Development of cardiovascular diseases mobilises endothelial progenitor cells (EPCs) from the bone marrow to participate in vascular repair and formation of new blood vessels under both pathological and physiological conditions. Therefore, EPCs show great potential for therapeutic applications; however, the phenotypic and functional characterisation of EPCs is still difficult because controversies exist regarding their accurate definition. Growing studies have shown modest clinical benefits of EPCs; however, it is necessary to better understand the regulation of EPC functions. MicroRNAs are small, non-coding, single-stranded RNAs with regulatory activities. Results of some recent studies have found that microRNAs play an important role in regulating EPC functions. In this review, we will summarise the results of some recent studies to provide an integral picture of the role of microRNAs in the regulation of EPC functions and will discuss the therapeutic applications and the new research direction. •MicroRNAs regulate the proliferation, differentiation and senescence of EPCs.•MicroRNAs regulate the mobilisation and migration of EPCs.•MicroRNAs regulate the ability of tubule structure formation of EPCs and EPCs-inducted angiogenesis.•MicroRNAs regulate other function of EPCs.•Related signalling pathways
AbstractList	Development of cardiovascular diseases mobilises endothelial progenitor cells (EPCs) from the bone marrow to participate in vascular repair and formation of new blood vessels under both pathological and physiological conditions. Therefore, EPCs show great potential for therapeutic applications; however, the phenotypic and functional characterisation of EPCs is still difficult because controversies exist regarding their accurate definition. Growing studies have shown modest clinical benefits of EPCs; however, it is necessary to better understand the regulation of EPC functions. MicroRNAs are small, non-coding, single-stranded RNAs with regulatory activities. Results of some recent studies have found that microRNAs play an important role in regulating EPC functions. In this review, we will summarise the results of some recent studies to provide an integral picture of the role of microRNAs in the regulation of EPC functions and will discuss the therapeutic applications and the new research direction. •MicroRNAs regulate the proliferation, differentiation and senescence of EPCs.•MicroRNAs regulate the mobilisation and migration of EPCs.•MicroRNAs regulate the ability of tubule structure formation of EPCs and EPCs-inducted angiogenesis.•MicroRNAs regulate other function of EPCs.•Related signalling pathways Development of cardiovascular diseases mobilises endothelial progenitor cells (EPCs) from the bone marrow to participate in vascular repair and formation of new blood vessels under both pathological and physiological conditions. Therefore, EPCs show great potential for therapeutic applications; however, the phenotypic and functional characterisation of EPCs is still difficult because controversies exist regarding their accurate definition. Growing studies have shown modest clinical benefits of EPCs; however, it is necessary to better understand the regulation of EPC functions. MicroRNAs are small, non-coding, single-stranded RNAs with regulatory activities. Results of some recent studies have found that microRNAs play an important role in regulating EPC functions. In this review, we will summarise the results of some recent studies to provide an integral picture of the role of microRNAs in the regulation of EPC functions and will discuss the therapeutic applications and the new research direction.Development of cardiovascular diseases mobilises endothelial progenitor cells (EPCs) from the bone marrow to participate in vascular repair and formation of new blood vessels under both pathological and physiological conditions. Therefore, EPCs show great potential for therapeutic applications; however, the phenotypic and functional characterisation of EPCs is still difficult because controversies exist regarding their accurate definition. Growing studies have shown modest clinical benefits of EPCs; however, it is necessary to better understand the regulation of EPC functions. MicroRNAs are small, non-coding, single-stranded RNAs with regulatory activities. Results of some recent studies have found that microRNAs play an important role in regulating EPC functions. In this review, we will summarise the results of some recent studies to provide an integral picture of the role of microRNAs in the regulation of EPC functions and will discuss the therapeutic applications and the new research direction. Development of cardiovascular diseases mobilises endothelial progenitor cells (EPCs) from the bone marrow to participate in vascular repair and formation of new blood vessels under both pathological and physiological conditions. Therefore, EPCs show great potential for therapeutic applications; however, the phenotypic and functional characterisation of EPCs is still difficult because controversies exist regarding their accurate definition. Growing studies have shown modest clinical benefits of EPCs; however, it is necessary to better understand the regulation of EPC functions. MicroRNAs are small, non-coding, single-stranded RNAs with regulatory activities. Results of some recent studies have found that microRNAs play an important role in regulating EPC functions. In this review, we will summarise the results of some recent studies to provide an integral picture of the role of microRNAs in the regulation of EPC functions and will discuss the therapeutic applications and the new research direction.
Author	Qu, Kai Lin, Xiao-long Wang, Zuo He, Xing-lan Zhang, Hai Zhang, Kai
Author_xml	– sequence: 1 givenname: Kai surname: Qu fullname: Qu, Kai organization: Institute of Cardiovascular Research, Key Laboratory for Atherosclerology of Hunan Province, University of South China, Hengyang, Hunan 421001, China – sequence: 2 givenname: Zuo surname: Wang fullname: Wang, Zuo email: smt121101@163.com organization: Institute of Cardiovascular Research, Key Laboratory for Atherosclerology of Hunan Province, University of South China, Hengyang, Hunan 421001, China – sequence: 3 givenname: Xiao-long surname: Lin fullname: Lin, Xiao-long organization: Department of Pathology, The Third People's Hospital of Huizhou, Guangdong, Huizhou 516002, China – sequence: 4 givenname: Kai surname: Zhang fullname: Zhang, Kai organization: The Second Hospital Affiliated to University of South China, Hengyang 421001, Hunan, China – sequence: 5 givenname: Xing-lan surname: He fullname: He, Xing-lan organization: Institute of Cardiovascular Research, Key Laboratory for Atherosclerology of Hunan Province, University of South China, Hengyang, Hunan 421001, China – sequence: 6 givenname: Hai surname: Zhang fullname: Zhang, Hai organization: Institute of Cardiovascular Research, Key Laboratory for Atherosclerology of Hunan Province, University of South China, Hengyang, Hunan 421001, China
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Snippet	Development of cardiovascular diseases mobilises endothelial progenitor cells (EPCs) from the bone marrow to participate in vascular repair and formation of...
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SubjectTerms	Angiogenesis Animals Cardiovascular diseases Endothelial progenitor cells Endothelial Progenitor Cells - cytology Endothelial Progenitor Cells - metabolism Humans MicroRNA MicroRNAs - metabolism
Title	MicroRNAs: Key regulators of endothelial progenitor cell functions
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