Synthesis and preliminary biological evaluation of radiolabeled 5-BDBD analogs as new candidate PET radioligands for P2X4 receptor - Wang, Min; Gao, Mingzhang; Meyer, Jill A.; Peters, Jonathan S.; Zarrinmayeh, Hamideh; Territo, Paul R.; Hutchins, Gary D.; Zheng, Qi-Huang (Bioorganic & medicinal chemistry, 2017)
Keywords: Adenosine Triphosphate - chemistry; Adenosine Triphosphate - metabolism; Azirines - chemical synthesis; Azirines - chemistry; Azirines - metabolism; Binding, Competitive; Biochemistry & Molecular Biology; Carbon Radioisotopes - chemistry; Chemistry; Chemistry, Medicinal; Chemistry, Organic; Competitive binding assay; Dihydropyridines - chemical synthesis; Dihydropyridines - chemistry; Dihydropyridines - metabolism; Fluorine Radioisotopes - chemistry; HEK293 Cells; Humans; Isotope Labeling; Life Sciences & Biomedicine; P2X4 receptor; Pharmacology & Pharmacy; Physical Sciences; Positron emission tomography (PET); Positron-Emission Tomography; Protein Binding; Radiolabeled 5-BDBD analogs; Radioligand depletion experiment; Radiopharmaceuticals - chemical synthesis; Radiopharmaceuticals - chemistry; Radiopharmaceuticals - metabolism; Radiosynthesis; Receptors, Purinergic P2X4 - chemistry; Receptors, Purinergic P2X4 - genetics; Receptors, Purinergic P2X4 - metabolism; Recombinant Proteins - biosynthesis; Recombinant Proteins - chemistry; Science & Technology; Competitive binding assay; Positron emission tomography (PET); Radiolabeled 5-BDBD analogs; Radioligand depletion experiment; P2X4 receptor; Radiosynthesis; AGENT; 1ST RADIOSYNTHESIS; BROMINATION; FULLY AUTOMATED SYNTHESIS; TAU TRACER; PURINERGIC RECEPTORS