Synthesis and preliminary biological evaluation of radiolabeled 5-BDBD analogs as new candidate PET radioligands for P2X4 receptor

[Display omitted] P2X4 receptor has become an interesting molecular target for treatment and PET imaging of neuroinflammation and associated brain diseases such as Alzheimer’s disease. This study reports the first design, synthesis, radiolabeling and biological evaluation of new candidate PET P2X4 r...

Full description

Saved in:
Bibliographic Details
Published inBioorganic & medicinal chemistry Vol. 25; no. 14; pp. 3835 - 3844
Main Authors Wang, Min, Gao, Mingzhang, Meyer, Jill A., Peters, Jonathan S., Zarrinmayeh, Hamideh, Territo, Paul R., Hutchins, Gary D., Zheng, Qi-Huang
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 15.07.2017
Elsevier
Subjects
Adenosine Triphosphate - chemistry
Adenosine Triphosphate - metabolism
Azirines - chemical synthesis
Azirines - chemistry
Azirines - metabolism
Binding, Competitive
Biochemistry & Molecular Biology
Carbon Radioisotopes - chemistry
Chemistry
Chemistry, Medicinal
Chemistry, Organic
Competitive binding assay
Dihydropyridines - chemical synthesis
Dihydropyridines - chemistry
Dihydropyridines - metabolism
Fluorine Radioisotopes - chemistry
HEK293 Cells
Humans
Isotope Labeling
Life Sciences & Biomedicine
P2X4 receptor
Pharmacology & Pharmacy
Physical Sciences
Positron emission tomography (PET)
Positron-Emission Tomography
Protein Binding
Radiolabeled 5-BDBD analogs
Radioligand depletion experiment
Radiopharmaceuticals - chemical synthesis
Radiopharmaceuticals - chemistry
Radiopharmaceuticals - metabolism
Radiosynthesis
Receptors, Purinergic P2X4 - chemistry
Receptors, Purinergic P2X4 - genetics
Receptors, Purinergic P2X4 - metabolism
Recombinant Proteins - biosynthesis
Recombinant Proteins - chemistry
Science & Technology
Competitive binding assay
Positron emission tomography (PET)
Radiolabeled 5-BDBD analogs
Radioligand depletion experiment
P2X4 receptor
Radiosynthesis
AGENT
1ST RADIOSYNTHESIS
BROMINATION
FULLY AUTOMATED SYNTHESIS
TAU TRACER
PURINERGIC RECEPTORS
Online AccessGet full text

Cover

Abstract [Display omitted] P2X4 receptor has become an interesting molecular target for treatment and PET imaging of neuroinflammation and associated brain diseases such as Alzheimer’s disease. This study reports the first design, synthesis, radiolabeling and biological evaluation of new candidate PET P2X4 receptor radioligands using 5-BDBD, a specific P2X4 receptor antagonist, as a scaffold. 5-(3-Hydroxyphenyl)-1-[11C]methyl-1,3-dihydro-2H-benzofuro[3,2-e][1,4]diazepin-2-one (N-[11C]Me-5-BDBD analog, [11C]9) and 5-(3-Bromophenyl)-1-[11C]methyl-1,3-dihydro-2H-benzofuro[3,2-e][1,4]diazepin-2-one (N-[11C]Me-5-BDBD, [11C]8c) were prepared from their corresponding desmethylated precursors with [11C]CH3OTf through N-[11C]methylation and isolated by HPLC combined with SPE in 30–50% decay corrected radiochemical yields with 370–1110GBq/µmol specific activity at EOB. 5-(3-[18F]Fluorophenyl)-1,3-dihydro-2H-benzofuro[3,2-e][1,4]diazepin-2-one ([18F]F-5-BDBD, [18F]5a) and 5-(3-(2-[18F]fluoroethoxy)phenyl)-1,3-dihydro-2H-benzofuro[3,2-e][1,4]diazepin-2-one ([18F]FE-5-BDBD, [18F]11) were prepared from their corresponding nitro- and tosylated precursors by nucleophilic substitution with K[18F]F/Kryptofix 2.2.2 and isolated by HPLC-SPE in 5–25% decay corrected radiochemical yields with 111–740GBq/µmol specific activity at EOB. The preliminary biological evaluation of radiolabeled 5-BDBD analogs indicated these new radioligands have similar biological activity with their parent compound 5-BDBD.
AbstractList P2X4 receptor has become an interesting molecular target for treatment and PET imaging of neuroinflammation and associated brain diseases such as Alzheimer's disease. This study reports the first design, synthesis, radiolabeling and biological evaluation of new candidate PET P2X4 receptor radioligands using 5-BDBD, a specific P2X4 receptor antagonist, as a scaffold. 5-(3-Hydroxyphenyl)-1-[ C]methyl-1,3-dihydro-2H-benzofuro[3,2-e][1,4]diazepin-2-one (N-[ C]Me-5-BDBD analog, [ C]9) and 5-(3-Bromophenyl)-1-[ C]methyl-1,3-dihydro-2H-benzofuro[3,2-e][1,4]diazepin-2-one (N-[ C]Me-5-BDBD, [ C]8c) were prepared from their corresponding desmethylated precursors with [ C]CH OTf through N-[ C]methylation and isolated by HPLC combined with SPE in 30-50% decay corrected radiochemical yields with 370-1110GBq/µmol specific activity at EOB. 5-(3-[ F]Fluorophenyl)-1,3-dihydro-2H-benzofuro[3,2-e][1,4]diazepin-2-one ([ F]F-5-BDBD, [ F]5a) and 5-(3-(2-[ F]fluoroethoxy)phenyl)-1,3-dihydro-2H-benzofuro[3,2-e][1,4]diazepin-2-one ([ F]FE-5-BDBD, [ F]11) were prepared from their corresponding nitro- and tosylated precursors by nucleophilic substitution with K[ F]F/Kryptofix 2.2.2 and isolated by HPLC-SPE in 5-25% decay corrected radiochemical yields with 111-740GBq/µmol specific activity at EOB. The preliminary biological evaluation of radiolabeled 5-BDBD analogs indicated these new radioligands have similar biological activity with their parent compound 5-BDBD.
[Display omitted] P2X4 receptor has become an interesting molecular target for treatment and PET imaging of neuroinflammation and associated brain diseases such as Alzheimer’s disease. This study reports the first design, synthesis, radiolabeling and biological evaluation of new candidate PET P2X4 receptor radioligands using 5-BDBD, a specific P2X4 receptor antagonist, as a scaffold. 5-(3-Hydroxyphenyl)-1-[11C]methyl-1,3-dihydro-2H-benzofuro[3,2-e][1,4]diazepin-2-one (N-[11C]Me-5-BDBD analog, [11C]9) and 5-(3-Bromophenyl)-1-[11C]methyl-1,3-dihydro-2H-benzofuro[3,2-e][1,4]diazepin-2-one (N-[11C]Me-5-BDBD, [11C]8c) were prepared from their corresponding desmethylated precursors with [11C]CH3OTf through N-[11C]methylation and isolated by HPLC combined with SPE in 30–50% decay corrected radiochemical yields with 370–1110GBq/µmol specific activity at EOB. 5-(3-[18F]Fluorophenyl)-1,3-dihydro-2H-benzofuro[3,2-e][1,4]diazepin-2-one ([18F]F-5-BDBD, [18F]5a) and 5-(3-(2-[18F]fluoroethoxy)phenyl)-1,3-dihydro-2H-benzofuro[3,2-e][1,4]diazepin-2-one ([18F]FE-5-BDBD, [18F]11) were prepared from their corresponding nitro- and tosylated precursors by nucleophilic substitution with K[18F]F/Kryptofix 2.2.2 and isolated by HPLC-SPE in 5–25% decay corrected radiochemical yields with 111–740GBq/µmol specific activity at EOB. The preliminary biological evaluation of radiolabeled 5-BDBD analogs indicated these new radioligands have similar biological activity with their parent compound 5-BDBD.
P2X4 receptor has become an interesting molecular target for treatment and PET imaging of neuroinflammation and associated brain diseases such as Alzheimer's disease. This study reports the first design, synthesis, radiolabeling and biological evaluation of new candidate PET P2X4 receptor radioligands using 5-BDBD, a specific P2X4 receptor antagonist, as a scaffold. 5-(3-Hydroxyphenyl)-1-[11C]methyl-1,3-dihydro-2H-benzofuro[3,2-e][1,4]diazepin-2-one (N-[11C]Me-5-BDBD analog, [11C]9) and 5-(3-Bromophenyl)-1-[11C]methyl-1,3-dihydro-2H-benzofuro[3,2-e][1,4]diazepin-2-one (N-[11C]Me-5-BDBD, [11C]8c) were prepared from their corresponding desmethylated precursors with [11C]CH3OTf through N-[11C]methylation and isolated by HPLC combined with SPE in 30-50% decay corrected radiochemical yields with 370-1110GBq/µmol specific activity at EOB. 5-(3-[18F]Fluorophenyl)-1,3-dihydro-2H-benzofuro[3,2-e][1,4]diazepin-2-one ([18F]F-5-BDBD, [18F]5a) and 5-(3-(2-[18F]fluoroethoxy)phenyl)-1,3-dihydro-2H-benzofuro[3,2-e][1,4]diazepin-2-one ([18F]FE-5-BDBD, [18F]11) were prepared from their corresponding nitro- and tosylated precursors by nucleophilic substitution with K[18F]F/Kryptofix 2.2.2 and isolated by HPLC-SPE in 5-25% decay corrected radiochemical yields with 111-740GBq/µmol specific activity at EOB. The preliminary biological evaluation of radiolabeled 5-BDBD analogs indicated these new radioligands have similar biological activity with their parent compound 5-BDBD.P2X4 receptor has become an interesting molecular target for treatment and PET imaging of neuroinflammation and associated brain diseases such as Alzheimer's disease. This study reports the first design, synthesis, radiolabeling and biological evaluation of new candidate PET P2X4 receptor radioligands using 5-BDBD, a specific P2X4 receptor antagonist, as a scaffold. 5-(3-Hydroxyphenyl)-1-[11C]methyl-1,3-dihydro-2H-benzofuro[3,2-e][1,4]diazepin-2-one (N-[11C]Me-5-BDBD analog, [11C]9) and 5-(3-Bromophenyl)-1-[11C]methyl-1,3-dihydro-2H-benzofuro[3,2-e][1,4]diazepin-2-one (N-[11C]Me-5-BDBD, [11C]8c) were prepared from their corresponding desmethylated precursors with [11C]CH3OTf through N-[11C]methylation and isolated by HPLC combined with SPE in 30-50% decay corrected radiochemical yields with 370-1110GBq/µmol specific activity at EOB. 5-(3-[18F]Fluorophenyl)-1,3-dihydro-2H-benzofuro[3,2-e][1,4]diazepin-2-one ([18F]F-5-BDBD, [18F]5a) and 5-(3-(2-[18F]fluoroethoxy)phenyl)-1,3-dihydro-2H-benzofuro[3,2-e][1,4]diazepin-2-one ([18F]FE-5-BDBD, [18F]11) were prepared from their corresponding nitro- and tosylated precursors by nucleophilic substitution with K[18F]F/Kryptofix 2.2.2 and isolated by HPLC-SPE in 5-25% decay corrected radiochemical yields with 111-740GBq/µmol specific activity at EOB. The preliminary biological evaluation of radiolabeled 5-BDBD analogs indicated these new radioligands have similar biological activity with their parent compound 5-BDBD.
P2X4 receptor has become an interesting molecular target for treatment and PET imaging of neuroinflammation and associated brain diseases such as Alzheimer's disease. This study reports the first design, synthesis, radiolabeling and biological evaluation of new candidate PET P2X4 receptor radioligands using 5-BDBD, a specific P2X4 receptor antagonist, as a scaffold. 5-(3-Hydroxyphenyl)-1[C-11]methyl-1,3-dihydro-2H-benzofuro[3,2-e][1,4]diazepin-2-one (N-[C-11]Me-5-BDBD analog, [C-11)9) and 5-(3-Bromophenyl)-1[C-11]methyl-1,3-dihydro-2H-benzofuro[3,2-e][1,4]diazepin-2-one (N-[C-11]Me-5-BDBD, [C-11]8c) were prepared from their corresponding desmethylated precursors with [C-11]CH3OTf through N-[C-11]methylation and isolated by HPLC combined with SPE in 30-50% decay corrected radiochemical yields with 370-1110 GBq/mu mol specific activity at EOB. 5-(3-[(18)]Fluorophenyl)-1,3-dihydro-2H-benzofuro[3,2-e][1,4]diazepin-2-one ([F-18]F-5-BDBD, [F-18]5a) and 5-(3-(2-[(18)]fluoroethoxy)phenyl)-1,3-dihydro-2H-benzofuro[3,2-e][1,4]diazepin-2-one ([F-18]E-5-BDBD, [F-18]11) were prepared from their corresponding nitro- and tosylated precursors by nucleophilic substitution with K[F-18]F/Kryptofix 2.2.2 and isolated by HPLC-SPE in 5-25% decay corrected radiochemical yields with 111-740 GBq/mu mol specific activity at EOB. The preliminary biological evaluation of radiolabeled 5-BDBD analogs indicated these new radioligands have similar biological activity with their parent compound 5-BDBD. (C) 2017 Elsevier Ltd. All rights reserved.
Author Hutchins, Gary D.
Peters, Jonathan S.
Zheng, Qi-Huang
Zarrinmayeh, Hamideh
Wang, Min
Gao, Mingzhang
Territo, Paul R.
Meyer, Jill A.
Author_xml – sequence: 1
  givenname: Min
  surname: Wang
  fullname: Wang, Min
– sequence: 2
  givenname: Mingzhang
  surname: Gao
  fullname: Gao, Mingzhang
– sequence: 3
  givenname: Jill A.
  surname: Meyer
  fullname: Meyer, Jill A.
– sequence: 4
  givenname: Jonathan S.
  surname: Peters
  fullname: Peters, Jonathan S.
– sequence: 5
  givenname: Hamideh
  surname: Zarrinmayeh
  fullname: Zarrinmayeh, Hamideh
– sequence: 6
  givenname: Paul R.
  surname: Territo
  fullname: Territo, Paul R.
– sequence: 7
  givenname: Gary D.
  surname: Hutchins
  fullname: Hutchins, Gary D.
– sequence: 8
  givenname: Qi-Huang
  surname: Zheng
  fullname: Zheng, Qi-Huang
  email: qzheng@iupui.edu
BackLink https://www.ncbi.nlm.nih.gov/pubmed/28554730$$D View this record in MEDLINE/PubMed
BookMark eNqNkk1rFTEUhoNU7G31B7iRLAWZMZnJfARX9rZ-QMGCFdyFTHKm5jI3uSaZlm795Z7rnbpwUSSLwDnvcxLe856QIx88EPKSs5Iz3r7dlMPWlBXjXcmaktX8CVlx0YqiriU_Iism275gvWyPyUlKG8ZYJSR_Ro6rvmlEV7MV-fX13ucfkFyi2lu6izC5rfM63tPBhSncOKMnCrd6mnV2wdMw0qgttvQAE1jaFGfnZ-cIaxTjkEQ93FGDw5zVGejVxfUCuBssJjqGSK-q74JGMLDLIT4nT0c9JXix3Kfk24eL6_Wn4vLLx8_r95eFEVzmQgijRWct17wawTQatG1l1w6jbJtOQzV2rMaChqFveskFcGtMbXgvbGWkqE_J68PcXQw_Z0hZbV0yME3aQ5iT4pLVUlSSSZS-WqTzsAWrdtFt0RL14BsK3hwEdzCEMRkH3sBfGRot8PRdt7e8RXX__-q1y3-cXofZZ0S7A2piSCnCqMzSz1G7SXGm9lFQG4VRUPsoKNYojAKS_B_y4cHHmHcHBnAPtw6iWj5rHW4rKxvcI_Rvm1HKLw
CitedBy_id crossref_primary_10_1016_j_neulet_2018_10_047
crossref_primary_10_1097_PR9_0000000000000864
crossref_primary_10_1016_j_bmcl_2019_04_018
crossref_primary_10_1177_1536012120927609
crossref_primary_10_1016_j_apradiso_2018_11_006
crossref_primary_10_1016_j_biopha_2020_110447
crossref_primary_10_1021_acsomega_9b04169
crossref_primary_10_1016_j_bmcl_2018_03_044
crossref_primary_10_1016_j_biopha_2022_114205
crossref_primary_10_2174_2772270817666230320124000
crossref_primary_10_1016_j_jocn_2022_03_009
crossref_primary_10_1124_molpharm_121_000402
crossref_primary_10_1007_s11302_024_10005_2
crossref_primary_10_1016_j_phrs_2020_104875
Cites_doi 10.1016/j.neuropharm.2015.10.031
10.1016/j.bmcl.2006.04.080
10.1002/bmc.494
10.1038/nature13085
10.2967/jnumed.116.181354
10.1016/j.bmcl.2014.07.092
10.1016/j.bmcl.2013.08.024
10.1016/j.bmcl.2015.08.053
10.1016/j.steroids.2011.06.012
10.1016/j.bcp.2016.11.016
10.1016/0883-2889(92)90012-4
10.1016/S0969-8051(98)00087-0
10.1016/j.apradiso.2009.09.071
10.1124/pr.110.003129
10.1002/adsc.201300844
10.1016/j.bmcl.2017.04.052
10.2302/kjm.2013-0003-RE
10.1159/000350119
10.1002/jlcr.1462
10.1021/jo01035a003
10.1002/jlcr.1599
10.1016/j.nucmedbio.2006.08.003
10.1016/j.apradiso.2012.03.011
10.1016/j.bmcl.2015.05.035
10.1016/j.bmcl.2015.03.021
10.1016/j.bmcl.2017.02.019
10.1016/j.bmcl.2011.12.136
10.2174/1871524913666131122160828
ContentType Journal Article
Copyright 2017 Elsevier Ltd
Copyright © 2017 Elsevier Ltd. All rights reserved.
Copyright_xml – notice: 2017 Elsevier Ltd
– notice: Copyright © 2017 Elsevier Ltd. All rights reserved.
DBID AAYXX
CITATION
17B
1KM
BLEPL
DTL
EGQ
GYRTJ
CGR
CUY
CVF
ECM
EIF
NPM
7X8
DOI 10.1016/j.bmc.2017.05.031
DatabaseName CrossRef
Web of Knowledge
Index Chemicus
Web of Science Core Collection
Science Citation Index Expanded
Web of Science Primary (SCIE, SSCI & AHCI)
Web of Science - Science Citation Index Expanded - 2017
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
MEDLINE - Academic
DatabaseTitle CrossRef
Web of Science
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
MEDLINE - Academic
DatabaseTitleList MEDLINE

MEDLINE - Academic
Web of Science
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: 1KM
  name: Index Chemicus
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/woscc/search-with-editions?editions=WOS.IC
  sourceTypes:
    Enrichment Source
    Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
Anatomy & Physiology
Chemistry
EISSN 1464-3391
EndPage 3844
ExternalDocumentID 28554730
000404087700026
10_1016_j_bmc_2017_05_031
S0968089617308246
Genre Research Support, U.S. Gov't, Non-P.H.S
Research Support, Non-U.S. Gov't
Journal Article
GrantInformation_xml – fundername: Advanced Imaging Research and Technology Development (AIRTD) grants from the Department of Radiology and Imaging Sciences at Indiana University School of Medicine in the United States
– fundername: Biomedical Research Grant from the Indiana University School of Medicine
– fundername: United States National Science Foundation (NSF) Major Research Instrumentation Program (MRI); National Science Foundation (NSF); NSF - Directorate for Biological Sciences (BIO)
  grantid: CHE-0619254
GroupedDBID ---
--K
--M
.~1
0R~
1B1
1RT
1~.
1~5
23N
4.4
457
4G.
5GY
5VS
7-5
71M
8P~
9JM
9JN
AABNK
AACTN
AAEDT
AAEDW
AAIAV
AAIKJ
AAKOC
AALRI
AAOAW
AAQFI
AARLI
AATCM
AAXUO
ABBQC
ABFNM
ABGSF
ABJNI
ABLVK
ABMAC
ABMZM
ABUDA
ABYKQ
ABZDS
ACDAQ
ACGFS
ACIUM
ACRLP
ADBBV
ADECG
ADEZE
ADUVX
AEBSH
AEHWI
AEKER
AENEX
AFKWA
AFTJW
AFXIZ
AFZHZ
AGUBO
AGYEJ
AHHHB
AIEXJ
AIKHN
AITUG
AJBFU
AJOXV
AJRQY
AJSZI
ALCLG
ALMA_UNASSIGNED_HOLDINGS
AMFUW
AMRAJ
ANZVX
AXJTR
BKOJK
BLXMC
BNPGV
CS3
DOVZS
DU5
EBS
EFJIC
EFLBG
EJD
EO8
EO9
EP2
EP3
F5P
FDB
FIRID
FLBIZ
FNPLU
FYGXN
G-Q
GBLVA
IHE
J1W
KOM
LCYCR
LZ2
M29
M2Z
M34
M41
MO0
N9A
O-L
O9-
OAUVE
OGGZJ
OZT
P-8
P-9
P2P
PC.
Q38
RIG
ROL
RPZ
SCC
SDF
SDG
SDP
SES
SPC
SPCBC
SSH
SSK
SSP
SSU
SSZ
T5K
UPT
XPP
YK3
~02
~G-
53G
AAQXK
AATTM
AAXKI
AAYWO
AAYXX
ABWVN
ABXDB
ACIEU
ACNNM
ACRPL
ACVFH
ADCNI
ADMUD
ADNMO
AEIPS
AEUPX
AFFNX
AFJKZ
AFPUW
AGCQF
AGHFR
AGQPQ
AGRDE
AGRNS
AIGII
AIIUN
AKBMS
AKRWK
AKYEP
ANKPU
APXCP
ASPBG
AVWKF
AZFZN
CITATION
FEDTE
FGOYB
G-2
HEA
HMK
HMO
HMS
HMT
HVGLF
HZ~
R2-
SAE
SCB
SEW
SOC
SPT
WUQ
ZMT
17B
1KM
BLEPL
DTL
EFKBS
GROUPED_WOS_SCIENCE_CITATION_INDEX_EXPANDED
GROUPED_WOS_WEB_OF_SCIENCE
CGR
CUY
CVF
ECM
EIF
NPM
7X8
ID FETCH-LOGICAL-c419t-44ca47dd1a12fec5aead6976bf9657ae2f703697aeb858914e1dcc3c184d2c943
IEDL.DBID .~1
ISICitedReferencesCount 17
ISICitedReferencesURI https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestApp=WOS&DestLinkType=CitingArticles&UT=000404087700026
ISSN 0968-0896
1464-3391
IngestDate Thu Jul 10 19:56:06 EDT 2025
Wed Feb 19 02:42:52 EST 2025
Wed Aug 06 08:40:27 EDT 2025
Fri Aug 29 16:13:06 EDT 2025
Tue Jul 01 00:47:09 EDT 2025
Thu Apr 24 23:05:17 EDT 2025
Fri Feb 23 02:14:27 EST 2024
IsPeerReviewed true
IsScholarly true
Issue 14
Keywords Competitive binding assay
Positron emission tomography (PET)
Radiolabeled 5-BDBD analogs
Radioligand depletion experiment
P2X4 receptor
Radiosynthesis
AGENT
1ST RADIOSYNTHESIS
BROMINATION
FULLY AUTOMATED SYNTHESIS
TAU TRACER
PURINERGIC RECEPTORS
Language English
License Copyright © 2017 Elsevier Ltd. All rights reserved.
LinkModel DirectLink
LogoURL https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg
MergedId FETCHMERGED-LOGICAL-c419t-44ca47dd1a12fec5aead6976bf9657ae2f703697aeb858914e1dcc3c184d2c943
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
PMID 28554730
PQID 1903942909
PQPubID 23479
PageCount 10
ParticipantIDs webofscience_primary_000404087700026
webofscience_primary_000404087700026CitationCount
proquest_miscellaneous_1903942909
crossref_citationtrail_10_1016_j_bmc_2017_05_031
crossref_primary_10_1016_j_bmc_2017_05_031
elsevier_sciencedirect_doi_10_1016_j_bmc_2017_05_031
pubmed_primary_28554730
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2017-07-15
PublicationDateYYYYMMDD 2017-07-15
PublicationDate_xml – month: 07
  year: 2017
  text: 2017-07-15
  day: 15
PublicationDecade 2010
PublicationPlace OXFORD
PublicationPlace_xml – name: OXFORD
– name: England
PublicationTitle Bioorganic & medicinal chemistry
PublicationTitleAbbrev BIOORGAN MED CHEM
PublicationTitleAlternate Bioorg Med Chem
PublicationYear 2017
Publisher Elsevier Ltd
Elsevier
Publisher_xml – name: Elsevier Ltd
– name: Elsevier
References Idzko, Ferrari, Eltzschig (b0015) 2014; 509
Wang, Gao, Miller, Sledge, Zheng (b0075) 2006; 16
Woods, Ajit, Camden, Erb, Weisman (b0020) 2016; 104
Wang, Gao, Xu, Zheng (b0090) 2017; 27
Wang, Gao, Miller, Zheng (b0105) 2011; 76
Balázs, Dankó, Kovács, Köles, Hediger, Zsembery (b0035) 2013; 32
Wang, Gao, Zheng (b0115) 2014; 24
Coddou, Yan, Obsil, Huidobro-Toro, Stojilkovic (b0005) 2011; 63
Wang, Gao, Xu, Zheng (b0085) 2015; 25
Abdelrahman, Namasivayam, Hinz (b0160) 2017; 125
Gao, Wang, Meyer (b0155) 2017; 27
Wang, Gao, Miller, Sledge, Zheng (b0110) 2012; 22
Burnstock (b0010) 2013; 62
King, Ostrum (b0055) 1964; 29
Wang, Gao, Miller, Sledge, Hutchins, Zheng (b0070) 2008; 51
Gao, Wang, Zheng (b0140) 2015; 25
Kuhnast, Hinnen, Dolle (b0150) 2009; 52
Wang, Gao, Zheng (b0120) 2013; 23
Gao, Wang, Green, Hutchins, Zheng (b0025) 2015; 25
Rowland, Tu, Xu, Ponde, Mach, Welch (b0045) 2006; 47
Boominathan, Hu, Senadi, Wang (b0060) 2013; 355
Lee, Finck, Jones, Welch, Mach (b0040) 2006; 33
Mock, Mulholland, Vavrek (b0100) 1999; 26
Mock, Glick-Wilson, Zheng, DeGrado (b0130) 2005; 48
Zheng, Mock (b0135) 2005; 19
Jewett (b0095) 1992; 43
Kamal, Shakya, Ahsan, Jawaid (b0050) 2013; 13
Mock, Zheng, DeGrado (b0125) 2005; 48
Fischer R, Kalthof B, Stelte-ludwig B, Woltering E, Wuttke M. CA 2519987 A1 2004.
Territo, Meyer, Peters (b0030) 2017; 58
Wang, Gao, Zheng (b0080) 2012; 70
Gao, Wang, Mock (b0145) 2010; 68
Gao (10.1016/j.bmc.2017.05.031_b0025) 2015; 25
Wang (10.1016/j.bmc.2017.05.031_b0090) 2017; 27
Wang (10.1016/j.bmc.2017.05.031_b0115) 2014; 24
Coddou (10.1016/j.bmc.2017.05.031_b0005) 2011; 63
Lee (10.1016/j.bmc.2017.05.031_b0040) 2006; 33
Balázs (10.1016/j.bmc.2017.05.031_b0035) 2013; 32
Kamal (10.1016/j.bmc.2017.05.031_b0050) 2013; 13
Wang (10.1016/j.bmc.2017.05.031_b0075) 2006; 16
Zheng (10.1016/j.bmc.2017.05.031_b0135) 2005; 19
Wang (10.1016/j.bmc.2017.05.031_b0070) 2008; 51
King (10.1016/j.bmc.2017.05.031_b0055) 1964; 29
Wang (10.1016/j.bmc.2017.05.031_b0120) 2013; 23
Gao (10.1016/j.bmc.2017.05.031_b0155) 2017; 27
Gao (10.1016/j.bmc.2017.05.031_b0140) 2015; 25
Boominathan (10.1016/j.bmc.2017.05.031_b0060) 2013; 355
Wang (10.1016/j.bmc.2017.05.031_b0085) 2015; 25
Mock (10.1016/j.bmc.2017.05.031_b0125) 2005; 48
Gao (10.1016/j.bmc.2017.05.031_b0145) 2010; 68
Idzko (10.1016/j.bmc.2017.05.031_b0015) 2014; 509
Jewett (10.1016/j.bmc.2017.05.031_b0095) 1992; 43
10.1016/j.bmc.2017.05.031_b0065
Wang (10.1016/j.bmc.2017.05.031_b0105) 2011; 76
Kuhnast (10.1016/j.bmc.2017.05.031_b0150) 2009; 52
Mock (10.1016/j.bmc.2017.05.031_b0130) 2005; 48
Woods (10.1016/j.bmc.2017.05.031_b0020) 2016; 104
Mock (10.1016/j.bmc.2017.05.031_b0100) 1999; 26
Wang (10.1016/j.bmc.2017.05.031_b0080) 2012; 70
Rowland (10.1016/j.bmc.2017.05.031_b0045) 2006; 47
Wang (10.1016/j.bmc.2017.05.031_b0110) 2012; 22
Abdelrahman (10.1016/j.bmc.2017.05.031_b0160) 2017; 125
Burnstock (10.1016/j.bmc.2017.05.031_b0010) 2013; 62
Territo (10.1016/j.bmc.2017.05.031_b0030) 2017; 58
Wang, M (WOS:000254586300002) 2008; 51
Idzko, M (WOS:000336121200029) 2014; 509
Abdelrahman, A (WOS:000393013600004) 2017; 125
Gao, MZ (WOS:000356101700015) 2015; 25
Mock, BH (WOS:000267210100221) 2005; 48
Balazs, B (WOS:000322731300002) 2013; 32
Lee, H (WOS:000241530100004) 2006; 33
JEWETT, DM (WOS:A1992JX49600012) 1992; 43
(000404087700026.1) 2004
Wang, M (WOS:000295745500014) 2011; 76
Wang, M (WOS:000362102200042) 2015; 25
Wang, M (WOS:000300404900016) 2012; 22
Wang, JQ (WOS:000239291900047) 2006; 16
Wang, M (WOS:000341435000020) 2014; 24
Wang, M (WOS:000304178500010) 2012; 70
Woods, LT (WOS:000377320300015) 2016; 104
Gao, MZ (WOS:000276422100017) 2010; 68
Kamal, Mehnaz (MEDLINE:24261837) 2013; 13
Zheng, QH (WOS:000233317000005) 2005; 19
Kuhnast, B (WOS:000268724900287) 2009; 52
Coddou, C (WOS:000292862800005) 2011; 63
Territo, PR (WOS:000395742700020) 2017; 58
Mock, BH (WOS:000080304600018) 1999; 26
Boominathan, SSK (WOS:000329021600011) 2013; 355
Wang, M (WOS:000324302800001) 2013; 23
Gao, MZ (WOS:000402472600016) 2017; 27
Mock, BH (WOS:000267210100222) 2005; 48
KING, LC (WOS:A19646301B00050) 1964; 29
Wang, M (WOS:000396798800004) 2017; 27
Gao, MZ (WOS:000353205000029) 2015; 25
Rowland, DJ (WOS:000238104800026) 2006; 47
Burnstock, Geoffrey (BCI:BCI201300748578) 2013; 62
References_xml – volume: 58
  start-page: 458
  year: 2017
  end-page: 465
  ident: b0030
  publication-title: J Nucl Med
– volume: 43
  start-page: 1383
  year: 1992
  end-page: 1385
  ident: b0095
  publication-title: Int J Rad Appl Instrum A
– volume: 76
  start-page: 1331
  year: 2011
  end-page: 1340
  ident: b0105
  publication-title: Steroids
– volume: 48
  start-page: S225
  year: 2005
  ident: b0125
  publication-title: J Label Compd Radiopharm
– volume: 19
  start-page: 671
  year: 2005
  end-page: 676
  ident: b0135
  publication-title: Biomed Chromatogr
– volume: 104
  start-page: 169
  year: 2016
  end-page: 179
  ident: b0020
  publication-title: Neuropharmacology
– volume: 24
  start-page: 4455
  year: 2014
  end-page: 4459
  ident: b0115
  publication-title: Bioorg Med Chem Lett
– volume: 29
  start-page: 3459
  year: 1964
  end-page: 3461
  ident: b0055
  publication-title: J Org Chem
– volume: 32
  start-page: 11
  year: 2013
  end-page: 24
  ident: b0035
  publication-title: Cell Physiol Biochem
– volume: 16
  start-page: 4102
  year: 2006
  end-page: 4106
  ident: b0075
  publication-title: Bioorg Med Chem Lett
– volume: 48
  start-page: S224
  year: 2005
  ident: b0130
  publication-title: J Label Compd Radiopharm
– volume: 51
  start-page: 6
  year: 2008
  end-page: 11
  ident: b0070
  publication-title: J Label Comp Radiopharm
– volume: 25
  start-page: 2953
  year: 2015
  end-page: 2957
  ident: b0140
  publication-title: Bioorg Med Chem Lett
– volume: 25
  start-page: 4587
  year: 2015
  end-page: 4592
  ident: b0085
  publication-title: Bioorg Med Chem Lett
– reference: Fischer R, Kalthof B, Stelte-ludwig B, Woltering E, Wuttke M. CA 2519987 A1 2004.
– volume: 509
  start-page: 310
  year: 2014
  end-page: 317
  ident: b0015
  publication-title: Nature
– volume: 25
  start-page: 1965
  year: 2015
  end-page: 1970
  ident: b0025
  publication-title: Bioorg Med Chem Lett
– volume: 27
  start-page: 1351
  year: 2017
  end-page: 1355
  ident: b0090
  publication-title: Bioorg Med Chem Lett
– volume: 22
  start-page: 1569
  year: 2012
  end-page: 1574
  ident: b0110
  publication-title: Bioorg Med Chem Lett
– volume: 33
  start-page: 847
  year: 2006
  end-page: 854
  ident: b0040
  publication-title: Nucl Med Biol
– volume: 125
  start-page: 41
  year: 2017
  end-page: 54
  ident: b0160
  publication-title: Biochem Pharmacol
– volume: 62
  start-page: 63
  year: 2013
  end-page: 73
  ident: b0010
  publication-title: Keio J Med
– volume: 70
  start-page: 965
  year: 2012
  end-page: 973
  ident: b0080
  publication-title: Appl Radiat Isot
– volume: 26
  start-page: 467
  year: 1999
  end-page: 471
  ident: b0100
  publication-title: Nucl Med Biol
– volume: 27
  start-page: 2727
  year: 2017
  end-page: 2730
  ident: b0155
  publication-title: Bioorg Med Chem Lett
– volume: 63
  start-page: 641
  year: 2011
  end-page: 683
  ident: b0005
  publication-title: Pharmacol Rev
– volume: 47
  start-page: 1041
  year: 2006
  end-page: 1048
  ident: b0045
  publication-title: J Nucl Med
– volume: 23
  start-page: 5259
  year: 2013
  end-page: 5263
  ident: b0120
  publication-title: Bioorg Med Chem Lett
– volume: 13
  start-page: 159
  year: 2013
  end-page: 165
  ident: b0050
  publication-title: Cent Nerv Syst Agents Med Chem
– volume: 355
  start-page: 3570
  year: 2013
  end-page: 3574
  ident: b0060
  publication-title: Adv Synth Catal
– volume: 68
  start-page: 1079
  year: 2010
  end-page: 1086
  ident: b0145
  publication-title: Appl Radiat Isot
– volume: 52
  start-page: S286
  year: 2009
  ident: b0150
  publication-title: J Label Compd Radiopharm
– volume: 104
  start-page: 169
  year: 2016
  ident: 10.1016/j.bmc.2017.05.031_b0020
  publication-title: Neuropharmacology
  doi: 10.1016/j.neuropharm.2015.10.031
– volume: 16
  start-page: 4102
  year: 2006
  ident: 10.1016/j.bmc.2017.05.031_b0075
  publication-title: Bioorg Med Chem Lett
  doi: 10.1016/j.bmcl.2006.04.080
– volume: 47
  start-page: 1041
  year: 2006
  ident: 10.1016/j.bmc.2017.05.031_b0045
  publication-title: J Nucl Med
– volume: 19
  start-page: 671
  year: 2005
  ident: 10.1016/j.bmc.2017.05.031_b0135
  publication-title: Biomed Chromatogr
  doi: 10.1002/bmc.494
– volume: 509
  start-page: 310
  year: 2014
  ident: 10.1016/j.bmc.2017.05.031_b0015
  publication-title: Nature
  doi: 10.1038/nature13085
– volume: 58
  start-page: 458
  year: 2017
  ident: 10.1016/j.bmc.2017.05.031_b0030
  publication-title: J Nucl Med
  doi: 10.2967/jnumed.116.181354
– volume: 24
  start-page: 4455
  year: 2014
  ident: 10.1016/j.bmc.2017.05.031_b0115
  publication-title: Bioorg Med Chem Lett
  doi: 10.1016/j.bmcl.2014.07.092
– volume: 23
  start-page: 5259
  year: 2013
  ident: 10.1016/j.bmc.2017.05.031_b0120
  publication-title: Bioorg Med Chem Lett
  doi: 10.1016/j.bmcl.2013.08.024
– volume: 25
  start-page: 4587
  year: 2015
  ident: 10.1016/j.bmc.2017.05.031_b0085
  publication-title: Bioorg Med Chem Lett
  doi: 10.1016/j.bmcl.2015.08.053
– ident: 10.1016/j.bmc.2017.05.031_b0065
– volume: 76
  start-page: 1331
  year: 2011
  ident: 10.1016/j.bmc.2017.05.031_b0105
  publication-title: Steroids
  doi: 10.1016/j.steroids.2011.06.012
– volume: 125
  start-page: 41
  year: 2017
  ident: 10.1016/j.bmc.2017.05.031_b0160
  publication-title: Biochem Pharmacol
  doi: 10.1016/j.bcp.2016.11.016
– volume: 43
  start-page: 1383
  year: 1992
  ident: 10.1016/j.bmc.2017.05.031_b0095
  publication-title: Int J Rad Appl Instrum A
  doi: 10.1016/0883-2889(92)90012-4
– volume: 26
  start-page: 467
  year: 1999
  ident: 10.1016/j.bmc.2017.05.031_b0100
  publication-title: Nucl Med Biol
  doi: 10.1016/S0969-8051(98)00087-0
– volume: 68
  start-page: 1079
  year: 2010
  ident: 10.1016/j.bmc.2017.05.031_b0145
  publication-title: Appl Radiat Isot
  doi: 10.1016/j.apradiso.2009.09.071
– volume: 63
  start-page: 641
  year: 2011
  ident: 10.1016/j.bmc.2017.05.031_b0005
  publication-title: Pharmacol Rev
  doi: 10.1124/pr.110.003129
– volume: 355
  start-page: 3570
  year: 2013
  ident: 10.1016/j.bmc.2017.05.031_b0060
  publication-title: Adv Synth Catal
  doi: 10.1002/adsc.201300844
– volume: 27
  start-page: 2727
  year: 2017
  ident: 10.1016/j.bmc.2017.05.031_b0155
  publication-title: Bioorg Med Chem Lett
  doi: 10.1016/j.bmcl.2017.04.052
– volume: 62
  start-page: 63
  year: 2013
  ident: 10.1016/j.bmc.2017.05.031_b0010
  publication-title: Keio J Med
  doi: 10.2302/kjm.2013-0003-RE
– volume: 32
  start-page: 11
  year: 2013
  ident: 10.1016/j.bmc.2017.05.031_b0035
  publication-title: Cell Physiol Biochem
  doi: 10.1159/000350119
– volume: 51
  start-page: 6
  year: 2008
  ident: 10.1016/j.bmc.2017.05.031_b0070
  publication-title: J Label Comp Radiopharm
  doi: 10.1002/jlcr.1462
– volume: 29
  start-page: 3459
  year: 1964
  ident: 10.1016/j.bmc.2017.05.031_b0055
  publication-title: J Org Chem
  doi: 10.1021/jo01035a003
– volume: 52
  start-page: S286
  year: 2009
  ident: 10.1016/j.bmc.2017.05.031_b0150
  publication-title: J Label Compd Radiopharm
  doi: 10.1002/jlcr.1599
– volume: 33
  start-page: 847
  year: 2006
  ident: 10.1016/j.bmc.2017.05.031_b0040
  publication-title: Nucl Med Biol
  doi: 10.1016/j.nucmedbio.2006.08.003
– volume: 70
  start-page: 965
  year: 2012
  ident: 10.1016/j.bmc.2017.05.031_b0080
  publication-title: Appl Radiat Isot
  doi: 10.1016/j.apradiso.2012.03.011
– volume: 25
  start-page: 2953
  year: 2015
  ident: 10.1016/j.bmc.2017.05.031_b0140
  publication-title: Bioorg Med Chem Lett
  doi: 10.1016/j.bmcl.2015.05.035
– volume: 48
  start-page: S225
  year: 2005
  ident: 10.1016/j.bmc.2017.05.031_b0125
  publication-title: J Label Compd Radiopharm
– volume: 25
  start-page: 1965
  year: 2015
  ident: 10.1016/j.bmc.2017.05.031_b0025
  publication-title: Bioorg Med Chem Lett
  doi: 10.1016/j.bmcl.2015.03.021
– volume: 27
  start-page: 1351
  year: 2017
  ident: 10.1016/j.bmc.2017.05.031_b0090
  publication-title: Bioorg Med Chem Lett
  doi: 10.1016/j.bmcl.2017.02.019
– volume: 22
  start-page: 1569
  year: 2012
  ident: 10.1016/j.bmc.2017.05.031_b0110
  publication-title: Bioorg Med Chem Lett
  doi: 10.1016/j.bmcl.2011.12.136
– volume: 48
  start-page: S224
  year: 2005
  ident: 10.1016/j.bmc.2017.05.031_b0130
  publication-title: J Label Compd Radiopharm
– volume: 13
  start-page: 159
  year: 2013
  ident: 10.1016/j.bmc.2017.05.031_b0050
  publication-title: Cent Nerv Syst Agents Med Chem
  doi: 10.2174/1871524913666131122160828
– volume: 27
  start-page: 1351
  year: 2017
  ident: WOS:000396798800004
  article-title: Synthesis of [C-11]HG-10-102-01 as a new potential PET agent for imaging of LRRK2 enzyme in Parkinson's disease
  publication-title: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
  doi: 10.1016/j.bmcl.2017.02.019
– volume: 51
  start-page: 6
  year: 2008
  ident: WOS:000254586300002
  article-title: Synthesis of new carbon-11-labeled 7-aroyl-aminoindoline-1-sulfonamides as potential PET agents for imaging of tubulin polymerization in cancers
  publication-title: JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
  doi: 10.1002/jlcr.1462
– volume: 63
  start-page: 641
  year: 2011
  ident: WOS:000292862800005
  article-title: Activation and Regulation of Purinergic P2X Receptor Channels
  publication-title: PHARMACOLOGICAL REVIEWS
  doi: 10.1124/pr.110.003129
– volume: 43
  start-page: 1383
  year: 1992
  ident: WOS:A1992JX49600012
  article-title: A SIMPLE SYNTHESIS OF [C-11] METHYL TRIFLATE
  publication-title: APPLIED RADIATION AND ISOTOPES
– volume: 355
  start-page: 3570
  year: 2013
  ident: WOS:000329021600011
  article-title: Silver(I)-Catalyzed Conia-Ene Reaction: Synthesis of 3-Pyrrolines via a 5-endo-dig Cyclization
  publication-title: ADVANCED SYNTHESIS & CATALYSIS
  doi: 10.1002/adsc.201300844
– volume: 29
  start-page: 3459
  year: 1964
  ident: WOS:A19646301B00050
  article-title: SELECTIVE BROMINATION WITH COPPER(2) BROMIDE
  publication-title: JOURNAL OF ORGANIC CHEMISTRY
– volume: 48
  start-page: S225
  year: 2005
  ident: WOS:000267210100222
  article-title: A MULTI-PURPOSE C-11-RADIOSYNTHESIS SYSTEM
  publication-title: JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
– volume: 16
  start-page: 4102
  year: 2006
  ident: WOS:000239291900047
  article-title: Synthesis of [C-11]Iressa as a new potential PET cancer imaging agent for epidermal growth factor receptor tyrosine kinase
  publication-title: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
  doi: 10.1016/j.bmcl.2006.04.080
– year: 2004
  ident: 000404087700026.1
– volume: 19
  start-page: 671
  year: 2005
  ident: WOS:000233317000005
  article-title: Purification of carbon-11 PET radiotracers from unlabeled precursors by preparative HPLC and SPE
  publication-title: BIOMEDICAL CHROMATOGRAPHY
  doi: 10.1002/bmc.494
– volume: 32
  start-page: 11
  year: 2013
  ident: WOS:000322731300002
  article-title: Investigation of the Inhibitory Effects of the Benzodiazepine Derivative, 5-BDBD on P2X(4) Purinergic Receptors by two Complementary Methods
  publication-title: CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
  doi: 10.1159/000350119
– volume: 23
  start-page: 5259
  year: 2013
  ident: WOS:000324302800001
  article-title: A high-yield route to synthesize the P-glycoprotein radioligand [C-11] N-desmethyl-loperamide and its parent radioligand [C-11] loperamide
  publication-title: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
  doi: 10.1016/j.bmcl.2013.08.024
– volume: 70
  start-page: 965
  year: 2012
  ident: WOS:000304178500010
  article-title: Fully automated synthesis of PET TSPO radioligands [C-11]DAA1106 and [F-18]FEDAA1106
  publication-title: APPLIED RADIATION AND ISOTOPES
  doi: 10.1016/j.apradiso.2012.03.011
– volume: 47
  start-page: 1041
  year: 2006
  ident: WOS:000238104800026
  article-title: Synthesis and in vivo evaluation of 2 high-affinity Br-76-labeledf sigma(2)-receptor ligands
  publication-title: JOURNAL OF NUCLEAR MEDICINE
– volume: 58
  start-page: 458
  year: 2017
  ident: WOS:000395742700020
  article-title: Characterization of C-11-GSK1482160 for Targeting the P2X7 Receptor as a Biomarker for Neuroinflammation
  publication-title: JOURNAL OF NUCLEAR MEDICINE
  doi: 10.2967/jnumed.116.181354
– volume: 52
  start-page: S286
  year: 2009
  ident: WOS:000268724900287
  article-title: PRODUCTION OF [18F]FALLYPRIDE ON A TRACERLAB FX-FN SYNTHESIZER
  publication-title: JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
– volume: 13
  start-page: 159
  year: 2013
  ident: MEDLINE:24261837
  article-title: Synthesis, anticonvulsant and neurotoxicity evaluation of some newer N-(2-benzoylbenzofuran-3-yl)-3-(substituted)-propanamide analogs.
  publication-title: Central nervous system agents in medicinal chemistry
– volume: 104
  start-page: 169
  year: 2016
  ident: WOS:000377320300015
  article-title: Purinergic receptors as potential therapeutic targets in Alzheimer's disease
  publication-title: NEUROPHARMACOLOGY
  doi: 10.1016/j.neuropharm.2015.10.031
– volume: 125
  start-page: 41
  year: 2017
  ident: WOS:000393013600004
  article-title: Characterization of P2X4 receptor agonists and antagonists by calcium influx and radioligand binding studies
  publication-title: BIOCHEMICAL PHARMACOLOGY
  doi: 10.1016/j.bcp.2016.11.016
– volume: 26
  start-page: 467
  year: 1999
  ident: WOS:000080304600018
  article-title: Convenient gas phase bromination of [C-11]methane and production of [C-11]methyl triflate
  publication-title: NUCLEAR MEDICINE AND BIOLOGY
– volume: 48
  start-page: S224
  year: 2005
  ident: WOS:000267210100221
  article-title: AUTOMATED MEASUREMENT OF SPECIFIC ACTIVITY OF RADIOLABELED LIGANDS DURING SYNTHESIS
  publication-title: JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
– volume: 27
  start-page: 2727
  year: 2017
  ident: WOS:000402472600016
  article-title: Synthesis and preliminary biological evaluation of [C-11]methyl (2-amino-5-(benzylthio)thiazolo[4,5-d]pyrimidin-7-yl)-D-leucinate for the fractalkine receptor (CX(3)CR1)
  publication-title: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
  doi: 10.1016/j.bmcl.2017.04.052
– volume: 22
  start-page: 1569
  year: 2012
  ident: WOS:000300404900016
  article-title: [C-11]GSK2126458 and [F-18]GSK2126458, the first radiosynthesis of new potential PET agents for imaging of PI3K and mTOR in cancers
  publication-title: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
  doi: 10.1016/j.bmcl.2011.12.136
– volume: 509
  start-page: 310
  year: 2014
  ident: WOS:000336121200029
  article-title: Nucleotide signalling during inflammation
  publication-title: NATURE
  doi: 10.1038/nature13085
– volume: 25
  start-page: 1965
  year: 2015
  ident: WOS:000353205000029
  article-title: Synthesis of [C-11]GSK1482160 as a new PET agent for targeting P2X(7) receptor
  publication-title: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
  doi: 10.1016/j.bmcl.2015.03.021
– volume: 68
  start-page: 1079
  year: 2010
  ident: WOS:000276422100017
  article-title: An improved synthesis of dopamine D-2/D-3 receptor radioligands [C-11]fallypride and [F-18]fallypride
  publication-title: APPLIED RADIATION AND ISOTOPES
  doi: 10.1016/j.apradiso.2009.09.071
– volume: 76
  start-page: 1331
  year: 2011
  ident: WOS:000295745500014
  article-title: Synthesis of [C-11]PBR06 and [F-18]PBR06 as agents for positron emission tomographic (PET) imaging of the translocator protein (TSPO)
  publication-title: STEROIDS
  doi: 10.1016/j.steroids.2011.06.012
– volume: 25
  start-page: 2953
  year: 2015
  ident: WOS:000356101700015
  article-title: Fully automated synthesis of [F-18]T807, a PET tau tracer for Alzheimer's disease
  publication-title: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
  doi: 10.1016/j.bmcl.2015.05.035
– volume: 62
  start-page: 63
  year: 2013
  ident: BCI:BCI201300748578
  article-title: Purinergic Signalling: Pathophysiology and Therapeutic Potential
  publication-title: Keio Journal of Medicine
  doi: 10.2302/kjm.2013-0003-RE
– volume: 24
  start-page: 4455
  year: 2014
  ident: WOS:000341435000020
  article-title: The first radiosynthesis of [C-11]AZD8931 as a new potential PET agent for imaging of EGFR, HER2 and HER3 signaling
  publication-title: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
  doi: 10.1016/j.bmcl.2014.07.092
– volume: 33
  start-page: 847
  year: 2006
  ident: WOS:000241530100004
  article-title: Synthesis and evaluation of a bromine-76-labeled PPAR gamma antagonist 2-bromo-5-nitro-N-phenylbenzamide
  publication-title: NUCLEAR MEDICINE AND BIOLOGY
  doi: 10.1016/j.nucmedbio.2006.08.003
– volume: 25
  start-page: 4587
  year: 2015
  ident: WOS:000362102200042
  article-title: Synthesis of a PET tau tracer [C-11]PBB3 for imaging of Alzheimer's disease
  publication-title: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
  doi: 10.1016/j.bmcl.2015.08.053
SSID ssj0002491
Score 2.3061135
Snippet [Display omitted] P2X4 receptor has become an interesting molecular target for treatment and PET imaging of neuroinflammation and associated brain diseases...
P2X4 receptor has become an interesting molecular target for treatment and PET imaging of neuroinflammation and associated brain diseases such as Alzheimer's...
Source Web of Science
SourceID proquest
pubmed
webofscience
crossref
elsevier
SourceType Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 3835
SubjectTerms Adenosine Triphosphate - chemistry
Adenosine Triphosphate - metabolism
Azirines - chemical synthesis
Azirines - chemistry
Azirines - metabolism
Binding, Competitive
Biochemistry & Molecular Biology
Carbon Radioisotopes - chemistry
Chemistry
Chemistry, Medicinal
Chemistry, Organic
Competitive binding assay
Dihydropyridines - chemical synthesis
Dihydropyridines - chemistry
Dihydropyridines - metabolism
Fluorine Radioisotopes - chemistry
HEK293 Cells
Humans
Isotope Labeling
Life Sciences & Biomedicine
P2X4 receptor
Pharmacology & Pharmacy
Physical Sciences
Positron emission tomography (PET)
Positron-Emission Tomography
Protein Binding
Radiolabeled 5-BDBD analogs
Radioligand depletion experiment
Radiopharmaceuticals - chemical synthesis
Radiopharmaceuticals - chemistry
Radiopharmaceuticals - metabolism
Radiosynthesis
Receptors, Purinergic P2X4 - chemistry
Receptors, Purinergic P2X4 - genetics
Receptors, Purinergic P2X4 - metabolism
Recombinant Proteins - biosynthesis
Recombinant Proteins - chemistry
Science & Technology
Title Synthesis and preliminary biological evaluation of radiolabeled 5-BDBD analogs as new candidate PET radioligands for P2X4 receptor
URI https://dx.doi.org/10.1016/j.bmc.2017.05.031
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestApp=WOS&DestLinkType=FullRecord&UT=000404087700026
https://www.ncbi.nlm.nih.gov/pubmed/28554730
https://www.proquest.com/docview/1903942909
Volume 25
WOS 000404087700026
WOSCitedRecordID wos000404087700026
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3db9MwED9NQwJeJuiAhY3JSBMPSKGx43w9dt2mAto0aZvUN8uxHVS0pVXbPfSFh_3lu0ucDgRMCOUlH3bk-C6-39nn3wEc6NTFwuk4tJWrQmlTHWqXidBmeeKiyPCipM3Jp2fp6Ep-GSfjDRh2e2EorNKP_e2Y3ozW_k7f92Z_Npn0LxB851FeoAkmyhVJtNtSZqTln348hHmge9FkzcPCIZXuVjabGK_yhlgMeUveGfO_2abfsecfzVRjkk5ewJbHkmzQNvclbLi6B9uDGv3omxX7wJrozmbavAfPhl1mtx48PfUL6ttwd7GqEQIuJguma8tmc3fdpPmar1hLz0QyZA-U4Gxasbm2-EiXaLAsS8LDo8MjrEyTQPiSBUOczgxtlqG5BHZ-fOkrTL7RrmKGIJmdi7Fk2O1uhh7_K7g6Ob4cjkKfliE0khfLUEqjZWYt11xUziQalTFFVFNWRZpk2omKSL0KPCtzylkoHbfGxAZ9SStMIePXsFlPa7cDDF1zXSLEclIYaTlhh9RmtspEZQtj8gCiTiDKeM5ySp1xrbrgtO8KZahIhipKFMowgI_rKrOWsOOxwrKTsvpF6xQalMeqve80QqHoaIlF1256u1AIr-ICTXxUBPCmVZV1KwRFBKKuBnDws-6snxO8xiPPMlLbNAD-L8WGvluIwmD59v--Zxee0xVNWfNkDzaX81v3DrHWstxvfqZ9eDL4_HV0dg_ujCeR
linkProvider Elsevier
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwEB6VIlEuCLY8wtNIFQcks3HiPHxst60W6FaVupX2Zjm2gxa12dXu9rAXDvxyZvLYgoAKoVyi2I4cz8TzjT3-BmDPpD6OvIm5K33JpUsNNz6LuMvyxIehFaqgw8mj03R4IT9NkskWDLqzMBRW2c79zZxez9btk347mv35dNo_R_Cdh7lCE0yUKzK9A3cl_r6UxuDDt5s4D_Qv6rR5WJtT9W5rsw7yKq6IxlA07J2x-Jtx-h18_tFO1Tbp-CE8aMEk22_6-wi2fNWD3f0KHemrNXvH6vDOet28BzuDLrVbD-6N2h31Xfh-vq4QAy6nS2Yqx-YLf1nn-VqsWcPPREJkN5zgbFayhXFYZAq0WI4l_ODw4BAb0yoQvmTJEKgzS6dlaDGBnR2N2wbTL3SsmCFKZmfRRDIcdz9Hl_8xXBwfjQdD3uZl4FYKteJSWiMz54QRUeltYlAbU4Q1RanSJDM-KonVS-FdkVPSQumFsza26Ey6yCoZP4Htalb5Z8DQNzcFYiwvIyudIPCQusyVWVQ6ZW0eQNgJRNuWtJxyZ1zqLjrtq0YZapKhDhONMgzg_abJvGHsuK2y7KSsf1E7jRbltmZvO43QKDraYzGVn10vNeKrWKGND1UATxtV2fQiopBAVNYA9n7WnU054Wu88iwjtU0DEP9SbdAOC3EYrJ7_3_e8gZ3heHSiTz6efn4B96mE1q9F8hK2V4tr_wqB16p4Xf9YPwBvsikf
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Synthesis+and+preliminary+biological+evaluation+of+radiolabeled+5-BDBD+analogs+as+new+candidate+PET+radioligands+for+P2X4+receptor&rft.jtitle=Bioorganic+%26+medicinal+chemistry&rft.au=Wang%2C+Min&rft.au=Gao%2C+Mingzhang&rft.au=Meyer%2C+Jill+A.&rft.au=Peters%2C+Jonathan+S.&rft.date=2017-07-15&rft.issn=0968-0896&rft.volume=25&rft.issue=14&rft.spage=3835&rft.epage=3844&rft_id=info:doi/10.1016%2Fj.bmc.2017.05.031&rft.externalDBID=n%2Fa&rft.externalDocID=10_1016_j_bmc_2017_05_031
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0968-0896&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0968-0896&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0968-0896&client=summon