Meflin-Positive Cancer-Associated Fibroblasts Inhibit Pancreatic Carcinogenesis

• Published in: Cancer research (Chicago, Ill.) Vol. 79; no. 20; pp. 5367 - 5381
• Main Authors: Mizutani, Yasuyuki, Kobayashi, Hiroki, Iida, Tadashi, Asai, Naoya, Masamune, Atsushi, Hara, Akitoshi, Esaki, Nobutoshi, Ushida, Kaori, Mii, Shinji, Shiraki, Yukihiro, Ando, Kenju, Weng, Liang, Ishihara, Seiichiro, Ponik, Suzanne M., Conklin, Matthew W., Haga, Hisashi, Nagasaka, Arata, Miyata, Takaki, Matsuyama, Makoto, Kobayashi, Tomoe, Fujii, Tsutomu, Yamada, Suguru, Yamaguchi, Junpei, Wang, Tongtong, Woods, Susan L., Worthley, Daniel, Shimamura, Teppei, Fujishiro, Mitsuhiro, Hirooka, Yoshiki, Enomoto, Atsushi, Takahashi, Masahide
• Format: Journal Article
• Language: English
• Published: United States 15.10.2019

Cancer-associated fibroblasts (CAF) constitute a major component of the tumor microenvironment. Recent observations in genetically engineered mouse models and clinical studies have suggested that there may exist at least two functionally different populations of CAFs, that is, cancer-promoting CAFs...