Differences in structural and functional networks between young adult and aged rat brains before and after stroke lesion simulations

• Published in: Neurobiology of disease Vol. 126; pp. 23 - 35
• Main Authors: Straathof, Milou, Sinke, Michel R.T., van der Toorn, Annette, Weerheim, Paul L., Otte, Willem M., Dijkhuizen, Rick M.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.06.2019; Elsevier
• Subjects: Age Factors; Aging; Animals; Brain - physiopathology; Diffusion MRI; Functional MRI; Graph theory; Lesion simulation; Male; Models, Neurological; Nerve Net - physiopathology; Network analysis; Rat brain; Rats; Rats, Wistar; Stroke; Stroke - physiopathology; Stroke; Lesion simulation; Network analysis; Aging; Diffusion MRI; Functional MRI; Graph theory; Rat brain

Neural network changes during aging may contribute to vulnerability and resilience to brain lesions in age-related neurological disorders, such as stroke. However, the relationship between age-related neural network features and stroke outcome is unknown. Therefore, we assessed structural and functi...