Antimanic activity of minocycline in a GBR12909-induced model of mania in mice: Possible role of antioxidant and neurotrophic mechanisms

• Published in: Journal of affective disorders Vol. 225; pp. 40 - 51
• Main Authors: de Queiroz, Ana Isabelle G., Chaves Filho, Adriano José Maia, Araújo, Tatiane da Silva, Lima, Camila Nayane Carvalho, Machado, Michel de Jesus Souza, Carvalho, André F., Vasconcelos, Silvania Maria Mendes, de Lucena, David Freitas, Quevedo, João, Macedo, Danielle
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.01.2018
• Subjects: Animals; Antimanic Agents - pharmacology; Antimanic Agents - therapeutic use; Antioxidants - pharmacology; Bipolar disorder; Bipolar Disorder - drug therapy; Brain - drug effects; Disease Models, Animal; GBR12909; Hippocampus - drug effects; Lipid Peroxidation; Lithium; Lithium - pharmacology; Lithium - therapeutic use; Male; Mania; Mice; Minocycline; Minocycline - pharmacology; Minocycline - therapeutic use; Risk taking behavior; Valproate; Valproic Acid - pharmacology; Valproic Acid - therapeutic use; Mania; Minocycline; Bipolar disorder; Lithium; GBR12909; Risk taking behavior; Valproate

Mania/hypomania is the cardinal feature of bipolar disorder. Recently, single administration of the dopamine transporter (DAT) inhibitor, GBR12909, was related to mania-like alterations. In the present study we aimed at testing behavioral and brain oxidant/neurotrophic alterations induced by the rep...