Increased levels of CSF CD59 in neuromyelitis optica and multiple sclerosis

• Published in: Clinica chimica acta Vol. 453; pp. 131 - 133
• Main Authors: Uzawa, Akiyuki, Mori, Masahiro, Uchida, Tomohiko, Masuda, Hiroki, Ohtani, Ryohei, Kuwabara, Satoshi
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 30.01.2016
• Subjects: Adult; CD59; CD59 Antigens - cerebrospinal fluid; Cerebrospinal fluid; Complement; Female; Humans; Interleukin-6; Male; Middle Aged; Multiple sclerosis; Multiple Sclerosis - cerebrospinal fluid; Neuromyelitis optica; Neuromyelitis Optica - cerebrospinal fluid; Multiple sclerosis; CD59; Complement; Neuromyelitis optica; Cerebrospinal fluid; Interleukin-6

Complement activation is important in multiple sclerosis (MS) and is essential for anti-aquaporin 4 antibodies to damage the central nervous system in neuromyelitis optica (NMO). Little is known about the role of cerebrospinal fluid (CSF) regulators of complement activation in NMO and MS. We determi...