Paris saponin VII extracted from Trillium tschonoskii induces autophagy and apoptosis in NSCLC cells

• Published in: Journal of ethnopharmacology Vol. 248; p. 112304
• Main Authors: Qian, Shijing, Tong, Shanshan, Wu, Juan, Tian, Lulu, Qi, Zhan, Chen, Beilei, Zhu, Deqiu, Zhang, Yan
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 10.02.2020
• Subjects: AMPK; Animals; Antineoplastic Agents, Phytogenic - pharmacology; Antineoplastic Agents, Phytogenic - therapeutic use; Apoptosis; Apoptosis - drug effects; Autophagy; Autophagy - drug effects; Carcinoma, Non-Small-Cell Lung - drug therapy; Cell Line, Tumor; Humans; Lung Neoplasms - drug therapy; Mice, Inbred BALB C; Mice, Nude; NSCLC; Saponins - pharmacology; Saponins - therapeutic use; Trillium; AMPK; NSCLC; Autophagy; Apoptosis

Trillium tschonoskii Maxim, a perennial herb of the Trilliaceae, has been widely used to treat inflammation, hypertension and cancer. We investigated Paris saponin VII's (PS VII), isolated from Trillium tschonoskii Maxim, function in mediating autophagy and apoptosis in NSCLC cells. We treated...