Laboratory evolution of protein conformational dynamics

• Published in: Current opinion in structural biology Vol. 50; pp. 49 - 57
• Main Authors: Campbell, Eleanor C, Correy, Galen J, Mabbitt, Peter D, Buckle, Ashley M, Tokuriki, Nobuhiko, Jackson, Colin J
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.06.2018
• Subjects: Computer Simulation; Evolution, Molecular; Molecular Dynamics Simulation; Protein Conformation; Protein Engineering; Proteins - chemistry; Proteins - genetics

•Laboratory directed evolution and ancestral reconstruction can facilitate study of protein structural dynamics.•Advances in biophysical and computational techniques facilitate this investigation.•Conformational dynamism is valuable in the acquisition of new function, as multiple potentially product...