Safety, tolerability, pharmacokinetics, and food effect of baicalein tablets in healthy Chinese subjects: A single-center, randomized, double-blind, placebo-controlled, single-dose phase I study

• Published in: Journal of ethnopharmacology Vol. 274; no. NA; p. 114052
• Main Authors: Dong, Ruihua, Li, Lijun, Gao, Hongzhi, Lou, Kun, Luo, Hongmei, Hao, Sheng, Yuan, Jing, Liu, Zeyuan
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 28.06.2021
• Subjects: Baicalein; blood; C-reactive protein; death; flavonoids; Food effect; humans; medical treatment; metabolites; Orthomyxoviridae; Pharmacokinetics; placebos; pneumonia; Safety; Scutellaria baicalensis; Tolerability; traditional medicine; urine; viruses; Baicalein; Tolerability; Food effect; Safety; Pharmacokinetics

Scutellaria baicalensis (Huang-Qin in Chinese) is a dry root of the perennial herb Scutellaria baicalensis Georgi, which has been used extensively in current prescriptions. Scutellaria baicalensis is an herb high in flavonoids, and baicalein is the one flavonoid found in the highest amount in Scutel...