Effect of itraconazole, food, and ethnic origin on the pharmacokinetics of ivosidenib in healthy subjects - Dai, David; Yang, Hua; Nabhan, Salah; Liu, Hua; Hickman, Denice; Liu, Guowen; Zacher, Jeffrey; Vutikullird, Apinya; Prakash, Chandra; Agresta, Samuel; Bowden, Chris; Fan, Bin (European journal of clinical pharmacology, 2019)
Keywords: Administration, Oral; Adult; Antifungal agents; Antineoplastic Agents - administration & dosage; Antineoplastic Agents - adverse effects; Antineoplastic Agents - pharmacokinetics; Area Under Curve; Asian Continental Ancestry Group; Biomedical and Life Sciences; Biomedicine; Clinical trials; Cross-Over Studies; Cytochrome P-450 CYP3A Inhibitors - pharmacology; Dehydrogenases; Dose-Response Relationship, Drug; Drug dosages; Drug Interactions - ethnology; Ethnicity; FDA approval; Female; Food; Food-Drug Interactions - ethnology; Gene expression; Glycine - administration & dosage; Glycine - adverse effects; Glycine - analogs & derivatives; Glycine - pharmacokinetics; Healthy Volunteers; Humans; Itraconazole; Itraconazole - administration & dosage; Itraconazole - pharmacology; Leukemia, Myeloid, Acute - drug therapy; Long QT Syndrome - diagnosis; Long QT Syndrome - epidemiology; Long QT Syndrome - etiology; Male; Metabolism; Middle Aged; Minority & ethnic groups; Mutation; Patients; Pharmaceuticals; Pharmacokinetics; Pharmacokinetics and Disposition; Pharmacology/Toxicology; Pyridines - administration & dosage; Pyridines - adverse effects; Pyridines - pharmacokinetics; Isocitrate dehydrogenase 1 inhibitor; CYP3A4 inhibitors; Drug interaction; Food effect; Pharmacokinetics; Ivosidenib