Acrylamide inhibits cellular differentiation of human neuroblastoma and glioblastoma cells

• Published in: Food and chemical toxicology Vol. 82; pp. 27 - 35
• Main Authors: Chen, Jong-Hang, Chou, Chin-Cheng
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.08.2015
• Subjects: Acrylamide; Acrylamide - toxicity; acrylamides; butyric acid; Butyric Acid - pharmacology; caffeine; cell differentiation; Cell Differentiation - drug effects; Cell Line, Tumor - drug effects; cell proliferation; Cell Proliferation - drug effects; Cellular differentiation; dose response; Down-Regulation - drug effects; Extracellular Signal-Regulated MAP Kinases - metabolism; Glioblastoma; Glioblastoma - drug therapy; Glioblastoma - metabolism; Glioblastoma - pathology; Humans; Janus Kinases - metabolism; mitogen-activated protein kinase; Neurites - drug effects; Neuroblastoma; Neuroblastoma - drug therapy; Neuroblastoma - metabolism; Neuroblastoma - pathology; neurogenesis; non-specific protein-tyrosine kinase; phosphorylation; Phosphorylation - drug effects; retinoic acid; Signal Transduction - drug effects; STAT Transcription Factors - metabolism; toxicology; Tretinoin - pharmacology; Acrylamide; Neuroblastoma; Cellular differentiation; Glioblastoma

•ACR attenuated RA-induced neurogenesis of SH-SY5Y and BA-induced astrogliogenesis of U-1240 MG.•ACR induced down regulation of MAPs expression and JAK-STAT signaling in cellular differentiation of SH-SY5Y and U-1240 MG.•ACR decreased the phosphorylation of ERK and JNK in glioblastoma cells. This st...