Role of the small intestine, colon and microbiota in determining the metabolic fate of polyphenols

• Published in: Biochemical pharmacology Vol. 139; pp. 24 - 39
• Main Authors: Williamson, Gary, Clifford, Michael N.
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 01.09.2017
• Subjects: Animals; Bioavailability; Biological Availability; Biotransformation; Colon - metabolism; Colon - microbiology; Conjugation; Diet, Healthy; Dietary Supplements; Digestion; Drugs, Chinese Herbal - analysis; Drugs, Chinese Herbal - pharmacokinetics; Gastrointestinal Microbiome; Glucosides - metabolism; Humans; Hydrolysis; Hydroxylation; Intestinal Absorption; Intestinal Mucosa - metabolism; Intestinal Mucosa - microbiology; Intestine, Small - metabolism; Intestine, Small - microbiology; Methylation; Microbiota; Organ Specificity; Phenolic acids; Polyphenols; Polyphenols - blood; Polyphenols - metabolism; Polyphenols - pharmacokinetics; Prebiotics - administration & dosage; Prebiotics - adverse effects; Polyphenols; Microbiota; Bioavailability; Conjugation; Phenolic acids

[Display omitted] (Poly)phenols are a large group of compounds, found in food, beverages, dietary supplements and herbal medicines. Owing to interest in their biological activities, absorption and metabolism of the most abundant compounds in humans are well understood. Both the chemical structure of...