Computing optimal drug dosing with OptiDose: implementation in NONMEM

• Published in: Journal of pharmacokinetics and pharmacodynamics Vol. 50; no. 3; pp. 173 - 188
• Main Authors: Bachmann, Freya, Koch, Gilbert, Bauer, Robert J., Steffens, Britta, Szinnai, Gabor, Pfister, Marc, Schropp, Johannes
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.06.2023; Springer Nature B.V
• Subjects: Algorithms; Biochemistry; Biomarkers; Biomedical and Life Sciences; Biomedical Engineering and Bioengineering; Biomedicine; Dosage; Drug dosages; Mathematical functions; Optimization; Original Paper; Pediatrics; Pharmacodynamics; Pharmacokinetics; Pharmacology/Toxicology; Pharmacy; Software; Veterinary Medicine/Veterinary Science; Optimal dosing; Dose optimization; Pharmacometrics; Therapeutic goal; Optimal control

Determining a drug dosing recommendation with a PKPD model can be a laborious and complex task. Recently, an optimal dosing algorithm (OptiDose) was developed to compute the optimal doses for any pharmacometrics/PKPD model for a given dosing scenario. In the present work, we reformulate the underlyi...