Sir David Cuthbertson Medal Lecture Bariatric surgery as a model to study appetite control

• Published in: Proceedings of the Nutrition Society Vol. 68; no. 3; pp. 227 - 233
• Main Authors: Bueter, Marco, le Roux, Carel W.
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Cambridge, UK Cambridge University Press 01.08.2009
• Subjects: appetite; Appetite - physiology; Appetite control model; Appetite Regulation; Appetite Regulation - physiology; Awards and Prizes; Bariatric Surgery; Biological and medical sciences; Brain; Brain - physiology; Brain - physiopathology; dietary restriction; Enteric Nervous System; Enteric Nervous System - physiology; Enteric Nervous System - physiopathology; Feeding. Feeding behavior; Fundamental and applied biological sciences. Psychology; gastrointestinal hormones; Gastrointestinal Hormones - physiology; ghrelin; Gut hormones; Humans; literature reviews; nutrition physiology; Obesity; Obesity - physiopathology; Obesity - surgery; physiological regulation; physiology; physiopathology; satiety; surgery; Vertebrates: anatomy and physiology, studies on body, several organs or systems; weight loss; Obesity; Appetite control model; Gut hormones; Bariatric surgery; Appetite; Hormone; Digestive system; Nutrition disorder; Gut; Vertebrata; Mammalia; Surgery; Models; Nutritional status
• DOI: 10.1017/S0029665109001256
• ISSN: 0029-6651; 1475-2719

The obesity epidemic and its associated morbidity and mortality have led to major research efforts to identify mechanisms that regulate appetite. Gut hormones have recently been found to be an important element in appetite regulation as a result of the signals from the periphery to the brain. Candidate hormones include ghrelin, peptide YY, glucagon-like peptide-1 and gastric inhibitory polypeptide, all of which are currently being investigated as potential obesity treatments. Bariatric surgery is currently the most effective therapy for substantial and sustained weight loss. Understanding how levels of gut hormones are modulated by such procedures has greatly contributed to the comprehension of the underlying mechanisms of appetite and obesity. The present paper is a review of how appetite and levels of gastrointestinal hormones are altered after bariatric surgery. Basic principles of common bariatric procedures and potential mechanisms for appetite regulation by gut hormones are also addressed.