Exhaled breath and fecal volatile organic biomarkers of chronic kidney disease

• Published in: Biochimica et biophysica acta Vol. 1830; no. 3; pp. 2531 - 2537
• Main Authors: Meinardi, Simone, Jin, Kyu-Bok, Barletta, Barbara, Blake, Donald R., Vaziri, Nosratola D.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.03.2013
• Subjects: air; aldehydes; Aldehydes - analysis; Aldehydes - metabolism; Animals; biomarkers; Biomarkers - analysis; Biomarkers - metabolism; body composition; body fluids; Breath Tests; Butadienes - analysis; Butadienes - metabolism; Chromatography, Gas; Disease Models, Animal; Disease Progression; Disulfides - analysis; Disulfides - metabolism; Exhalation; feces; Feces - chemistry; gas chromatography; gases; Gases - analysis; Gases - metabolism; Gastrointestinal tract; Hemiterpenes - analysis; Hemiterpenes - metabolism; Humans; Inflammation; Intestinal microbial flora; intestinal microorganisms; isoprene; kidney diseases; Male; metabolism; Metagenome; Microbiome; Nephrectomy; Pentanes - analysis; Pentanes - metabolism; Rats; Renal Insufficiency, Chronic - metabolism; Renal Insufficiency, Chronic - pathology; Sulfides - analysis; Sulfides - metabolism; Uremia; volatile organic compounds; Volatile Organic Compounds - analysis; Volatile Organic Compounds - metabolism; Inflammation; Gastrointestinal tract; Intestinal microbial flora; Uremia; Microbiome

While much is known about the effect of chronic kidney disease (CKD) on composition of body fluids little is known regarding its impact on the gases found in exhaled breath or produced by intestinal microbiome. We have recently shown significant changes in the composition of intestinal microbiome in...