Hidradenitis Suppurativa Is Characterized by Dysregulation of the Th17:Treg Cell Axis, Which Is Corrected by Anti-TNF Therapy

• Published in: Journal of investigative dermatology Vol. 137; no. 11; pp. 2389 - 2395
• Main Authors: Moran, Barry, Sweeney, Cheryl M., Hughes, Rosalind, Malara, Anna, Kirthi, Shivashini, Tobin, Anne-Marie, Kirby, Brian, Fletcher, Jean M.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.11.2017
• Subjects: Adult; Biopsy, Needle; Case-Control Studies; Cells, Cultured - drug effects; Cohort Studies; Female; Hidradenitis Suppurativa - drug therapy; Hidradenitis Suppurativa - immunology; Hidradenitis Suppurativa - pathology; Humans; Immunity, Cellular - drug effects; Immunity, Cellular - physiology; Immunohistochemistry; Interleukin-17 - immunology; Interleukin-17 - metabolism; Male; Reference Values; T-Lymphocytes, Regulatory - drug effects; T-Lymphocytes, Regulatory - immunology; T-Lymphocytes, Regulatory - metabolism; Th17 Cells - immunology; Th17 Cells - metabolism; Tumor Necrosis Factor-alpha - antagonists & inhibitors; Tumor Necrosis Factor-alpha - pharmacology; PBS; PG; Treg; Th cell; HS; PBMC; TNF

Hidradenitis suppurativa (HS) is a chronic, inflammatory, and debilitating disease of hair follicles with 1–4% prevalence and high morbidity. There is a dearth of information on the pathogenesis and immune dysregulation underlying HS; therefore, we carried out a detailed analysis of skin-infiltratin...