Mind bomb 2 limits inflammatory dermatitis in Sharpin mutant mice independently of cell death

• Published in: PNAS nexus Vol. 3; no. 1; p. pgad438
• Main Authors: Simpson, Daniel S, Anderton, Holly, Yousef, Jumana, Vaibhav, Vineet, Cobbold, Simon A, Bandala-Sanchez, Esther, Kueh, Andrew J, Dagley, Laura F, Herold, Marco J, Silke, John, Vince, James E, Feltham, Rebecca
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.01.2024
• Subjects: Analysis; Biological, Health, and Medical Sciences; Cell death; Dermatitis; Genetic aspects; Identification and classification; Inflammation; Properties; Skin; Ubiquitin; Australia; cpdm; dermatitis; mind bomb 2; TNF; Sharpin

Skin inflammation is a complex process implicated in various dermatological disorders. The chronic proliferative dermatitis (cpd) phenotype driven by the cpd mutation (cpdm) in the Sharpin gene is characterized by dermal inflammation and epidermal abnormalities. Tumour necrosis factor (TNF) and casp...