On the mechanisms for the selective action of vitamin D analogs

• Published in: Endocrinology (Philadelphia) Vol. 128; no. 4; p. 1687
• Main Authors: Dusso, A S, Negrea, L, Gunawardhana, S, Lopez-Hilker, S, Finch, J, Mori, T, Nishii, Y, Slatopolsky, E, Brown, A J
• Format: Journal Article
• Language: English
• Published: United States 01.04.1991
• Subjects: Animals; Binding, Competitive; Calcitriol - analogs & derivatives; Calcitriol - metabolism; Calcitriol - pharmacokinetics; Calcitriol - pharmacology; Calcium - blood; Dogs; Humans; Macrophages - drug effects; Macrophages - metabolism; Metabolic Clearance Rate; Nephrectomy; Parathyroid Hormone - secretion; Rats; Uremia - etiology; Uremia - metabolism; Vitamin D-Binding Protein - metabolism

A variety of analogs of 1,25-(OH)2D3 with less calcemic activity and lower receptor binding affinity than 1,25-(OH)2D3 have been developed. However, these compounds have equal or greater ability to differentiate leukemia cells and psoriatic fibroblasts and to suppress PTH synthesis and secretion. Th...