Combining fluorescence and permeability measurements in a membrane microfluidic device to study protein sorption mechanisms

• Published in: Journal of membrane science Vol. 614; p. 118485
• Main Authors: Bacchin, P., Snisarenko, D., Stamatialis, D., Aimar, P., Causserand, C.
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 15.11.2020; Elsevier
• Subjects: Adsorption; artificial membranes; Biological Physics; bovine serum albumin; Chemical engineering; Chemical Sciences; filtration; Fluorescence; fouling; hemodialysis; kidneys; lactalbumin; membrane permeability; Microfluidic; organ-on-a-chip; Physics; Protein; Ultrafiltration; Fluorescence; Ultrafiltration; Adsorption; Protein; Microfluidic; Membrane; Dialysis; Modelling; Clearance; Kidney

Membrane fouling by proteins is an important problem in hemodialysis or hemofiltration (artificial kidney). The mechanisms leading to fouling are still not fully understood and then predictable. In this paper we describe a microfluidic chip fitted with a filtration membrane which allows the real tim...