Combining fluorescence and permeability measurements in a membrane microfluidic device to study protein sorption mechanisms
Membrane fouling by proteins is an important problem in hemodialysis or hemofiltration (artificial kidney). The mechanisms leading to fouling are still not fully understood and then predictable. In this paper we describe a microfluidic chip fitted with a filtration membrane which allows the real tim...
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| Published in | Journal of membrane science Vol. 614; p. 118485 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Elsevier B.V
15.11.2020
Elsevier |
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| Abstract | Membrane fouling by proteins is an important problem in hemodialysis or hemofiltration (artificial kidney). The mechanisms leading to fouling are still not fully understood and then predictable. In this paper we describe a microfluidic chip fitted with a filtration membrane which allows the real time in situ fluorescent analysis of labelled proteins and the measurement of the membrane permeability. The apparent kinetics rates of adsorption derived from the changes in fluorescence signal are combined with permeability measurements. This allows to discriminate two clearly distinct fouling mechanism by Bovine Serum Albumin (BSA) and α-lactalbumin (LALBA). The fouling kinetics of BSA is very rapid, independent of the flow conditions and can then be viewed as a protein monolayer adsorption controlled by protein-membrane interactions. In contrast, the fouling kinetics by LALBA is slower and very sensitive to flow conditions. We also describe a fluorescence quenching induced by protein aggregation and compression at high permeation rate. The fouling mechanism can then be viewed as a flow induced aggregation followed by a deposition of aggregates on the membrane. The complexity of sorption mechanisms on membrane during cross-flow filtration can be unraveled with this experimental set-up.
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•Real time fluorescence microscopy in microfluidic devices tracks protein adsorption.•BSA monolayer adsorption was found fast and not sensitive to the flow conditions.•α-lactalbumin is subject to slow aggregation induced by the permeation flow.•High filtration rates lead to α-lactalbumin fluorescence quenching due to aggregation. |
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| AbstractList | Membrane fouling by proteins is an important problem in hemodialysis or hemofiltration (artificial kidney). The mechanisms leading to fouling are still not fully understood and then predictable. In this paper we describe a microfluidic chip fitted with a filtration membrane which allows the real time in situ fluorescent analysis of labelled proteins and the measurement of the membrane permeability. The apparent kinetics rates of adsorption derived from the changes in fluorescence signal are combined with permeability measurements. This allows to discriminate two clearly distinct fouling mechanism by Bovine Serum Albumin (BSA) and α-lactalbumin (LALBA). The fouling kinetics of BSA is very rapid, independent of the flow conditions and can then be viewed as a protein monolayer adsorption controlled by protein-membrane interactions. In contrast, the fouling kinetics by LALBA is slower and very sensitive to flow conditions. We also describe a fluorescence quenching induced by protein aggregation and compression at high permeation rate. The fouling mechanism can then be viewed as a flow induced aggregation followed by a deposition of aggregates on the membrane. The complexity of sorption mechanisms on membrane during cross-flow filtration can be unraveled with this experimental set-up. Membrane fouling by proteins is an important problem in hemodialysis or hemofiltration (artificial kidney). The mechanisms leading to fouling are still not fully understood and then predictable. In this paper we describe a microfluidic chip fitted with a filtration membrane which allows the real time in situ fluorescent analysis of labelled proteins and the measurement of the membrane permeability. The apparent kinetics rates of adsorption derived from the changes in fluorescence signal are combined with permeability measurements. This allows to discriminate two clearly distinct fouling mechanism by Bovine Serum Albumin (BSA) and α-lactalbumin (LALBA). The fouling kinetics of BSA is very rapid, independent of the flow conditions and can then be viewed as a protein monolayer adsorption controlled by protein-membrane interactions. In contrast, the fouling kinetics by LALBA is slower and very sensitive to flow conditions. We also describe a fluorescence quenching induced by protein aggregation and compression at high permeation rate. The fouling mechanism can then be viewed as a flow induced aggregation followed by a deposition of aggregates on the membrane. The complexity of sorption mechanisms on membrane during cross-flow filtration can be unraveled with this experimental set-up. [Display omitted] •Real time fluorescence microscopy in microfluidic devices tracks protein adsorption.•BSA monolayer adsorption was found fast and not sensitive to the flow conditions.•α-lactalbumin is subject to slow aggregation induced by the permeation flow.•High filtration rates lead to α-lactalbumin fluorescence quenching due to aggregation. |
| ArticleNumber | 118485 |
| Author | Stamatialis, D. Causserand, C. Aimar, P. Bacchin, P. Snisarenko, D. |
| Author_xml | – sequence: 1 givenname: P. surname: Bacchin fullname: Bacchin, P. email: patrice.bacchin@univ-tlse3.fr organization: Laboratoire de Génie Chimique, Université de Toulouse, CNRS, INPT, UPS, Toulouse, France – sequence: 2 givenname: D. surname: Snisarenko fullname: Snisarenko, D. organization: Laboratoire de Génie Chimique, Université de Toulouse, CNRS, INPT, UPS, Toulouse, France – sequence: 3 givenname: D. surname: Stamatialis fullname: Stamatialis, D. organization: (Bio)Artificial Organs, Department of Biomaterials Science and Technology, TechMed Centre, Faculty of Science and Technology, University of Twente, Drienerlolaan 5, 7500, AE Enschede, Netherlands – sequence: 4 givenname: P. surname: Aimar fullname: Aimar, P. organization: Laboratoire de Génie Chimique, Université de Toulouse, CNRS, INPT, UPS, Toulouse, France – sequence: 5 givenname: C. surname: Causserand fullname: Causserand, C. organization: Laboratoire de Génie Chimique, Université de Toulouse, CNRS, INPT, UPS, Toulouse, France |
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| Keywords | Fluorescence Ultrafiltration Adsorption Protein Microfluidic Membrane Dialysis Modelling Clearance Kidney |
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| SubjectTerms | Adsorption artificial membranes Biological Physics bovine serum albumin Chemical engineering Chemical Sciences filtration Fluorescence fouling hemodialysis kidneys lactalbumin membrane permeability Microfluidic organ-on-a-chip Physics Protein Ultrafiltration |
| Title | Combining fluorescence and permeability measurements in a membrane microfluidic device to study protein sorption mechanisms |
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