A pentapeptide signature motif plays a pivotal role in Leishmania DNA topoisomerase IB activity and camptothecin sensitivity - Prada, Christopher F.; Álvarez-Velilla, Raquel; Diaz-González, Rosario; Prieto, Carlos; Pérez-Pertejo, Yolanda; Balaña-Fouce, Rafael; Reguera, Rosa M. (Biochimica et biophysica acta, 2012)
Keywords: amino acids; Camptothecin - pharmacology; Camptothecin sensitivity; DNA; DNA topoisomerase; DNA topoisomerase IB; DNA Topoisomerases, Type I - chemistry; DNA Topoisomerases, Type I - genetics; DNA Topoisomerases, Type I - metabolism; DNA, Protozoan - chemistry; DNA, Protozoan - genetics; Drug Resistance; Humans; Leishmania donovani; Leishmania donovani - drug effects; Leishmania donovani - enzymology; Linker domain; Mutagenesis, Site-Directed; mutation; Mutation - genetics; Peptide Fragments - genetics; Peptide Fragments - metabolism; Protein interactions; Relaxation activity; therapeutics; Topoisomerase I Inhibitors - pharmacology; visceral leishmaniasis; LdTopIB; DNA topoisomerase IB; CPT; Leishmania donovani; Linker domain; CL; Relaxation activity; hTopIB; Protein interactions; LdTopIL; Top; LdTopIS; Camptothecin sensitivity