Chronic cerebral hypoperfusion independently exacerbates cognitive impairment within the pathopoiesis of Parkinson's disease via microvascular pathologys

• Published in: Behavioural brain research Vol. 333; pp. 286 - 294
• Main Authors: Tang, Hongmei, Gao, Yuyuan, Zhang, Qingxi, Nie, Kun, Zhu, Ruiming, Gao, Liang, Feng, Shujun, Wang, Limin, Zhao, Jiehao, Huang, Zhiheng, Zhang, Yuhu, Wang, Lijuan
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 30.08.2017
• Subjects: Animals; Antigens, CD34 - metabolism; Carotid Artery Diseases - complications; Cerebral microvascular impairment; Chronic cerebral hypoperfusion; Cognition Disorders - etiology; Cognition Disorders - pathology; Cognitive impairment; Disease Models, Animal; Exploratory Behavior - physiology; Learning Disorders - etiology; Male; Mice; Mice, Inbred C57BL; Microscopy, Electron, Transmission; Microvessels - pathology; Microvessels - ultrastructure; Mitogen-Activated Protein Kinase Kinases - metabolism; Movement - physiology; MPTP; Oncogene Protein v-akt - metabolism; Parkinson's disease; Parkinsonian Disorders - complications; Zonula Occludens-1 Protein - metabolism; BCCA; Cerebral microvascular impairment; CHH; BBB; AD; Parkinson's disease; NVU; PD-MCI; MPTP-P; PD; BCCAs; WML; PDCN; Chronic cerebral hypoperfusion; MPTP; Cognitive impairment
• ISSN: 0166-4328; 1872-7549; 1872-7549
• DOI: 10.1016/j.bbr.2017.05.061

•The combined lesion-induced perturbation elucidated the synergistic cerebral microvascular damage through the interaction of CHH and MPTP.•CHH is an independent exacerbating reason for cognitive impairment within the pathopoiesis of PD.•CHH and MPTP-lesioned mice showed impaired cerebral microvascu...