Effects of a sedative antihistamine, D-chlorpheniramine, on regional cerebral perfusion and performance during simulated car driving

Objectives The sedative side effects of antihistamines have been recognized to be potentially dangerous in car driving, but the mechanism underlying these effects has not yet been elucidated to date. The aim of the present study is to examine regional cerebral blood flow (rCBF) responses during a si...

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Published in	Human psychopharmacology Vol. 23; no. 2; pp. 139 - 150
Main Authors	Tashiro, Manabu, Sakurada, Yumiko, Mochizuki, Hideki, Horikawa, Etsuo, Maruyama, Masahiro, Okamura, Nobuyuki, Watanuki, Shoichi, Arai, Hiroyuki, Itoh, Masatoshi, Yanai, Kazuhiko
Format	Journal Article
Language	English
Published	Chichester, UK John Wiley & Sons, Ltd 01.03.2008
Subjects	Administration, Oral Adult antihistamine Automobile Driving Brain - blood supply Brain - drug effects car driving cerebral blood flow Cerebrovascular Circulation - drug effects Chlorpheniramine - pharmacology Cross-Over Studies Functional Laterality Histamine H1 Antagonists - pharmacology Humans impaired performance Male PET Positron-Emission Tomography Psychomotor Performance - drug effects Space Perception - drug effects Videotape Recording Visual Perception - drug effects
Online Access	Get full text
ISSN	0885-6222 1099-1077 1099-1077
DOI	10.1002/hup.909

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Abstract	Objectives The sedative side effects of antihistamines have been recognized to be potentially dangerous in car driving, but the mechanism underlying these effects has not yet been elucidated to date. The aim of the present study is to examine regional cerebral blood flow (rCBF) responses during a simulated car‐driving task following oral administration of D‐chlorpheniramine using positron emission tomography (PET) and [15O]H2O, based on a single‐blind cross‐over study‐design. Methods Right‐handed, healthy male volunteers (n = 14) drove a car in a simulated environment following oral administration of D‐chlorpheniramine repetab 6 mg or placebo. Their rCBF was measured using PET with [15O]H2O in the following three conditions: (1) resting, (2) active driving, and (3) passive driving. All ‘in‐car’ views during the simulated driving were videotaped and used for rating driving performance. Results Performance evaluation revealed that the number of lane deviations significantly increased in the D‐chlorpheniramine condition compared with the placebo condition (p < 0.01). Subjective sleepiness was not significantly different between the two drug conditions. The regions of diminished brain responses following D‐chlorpheniramine treatment were detected in the parietal, temporal and visual cortices, and in the cerebellum. The regions of augmented rCBF responses were found in the orbitofrontal cortex and cerebellar vermis. Conclusion These results suggest that D‐chlorpheniramine tends to suppress visuo‐spatial cognition and visuo‐motor coordinating functions rather than attention and motor functions during car driving. Copyright © 2008 John Wiley & Sons, Ltd.
AbstractList	Objectives The sedative side effects of antihistamines have been recognized to be potentially dangerous in car driving, but the mechanism underlying these effects has not yet been elucidated to date. The aim of the present study is to examine regional cerebral blood flow (rCBF) responses during a simulated car‐driving task following oral administration of D‐chlorpheniramine using positron emission tomography (PET) and [15O]H2O, based on a single‐blind cross‐over study‐design. Methods Right‐handed, healthy male volunteers (n = 14) drove a car in a simulated environment following oral administration of D‐chlorpheniramine repetab 6 mg or placebo. Their rCBF was measured using PET with [15O]H2O in the following three conditions: (1) resting, (2) active driving, and (3) passive driving. All ‘in‐car’ views during the simulated driving were videotaped and used for rating driving performance. Results Performance evaluation revealed that the number of lane deviations significantly increased in the D‐chlorpheniramine condition compared with the placebo condition (p < 0.01). Subjective sleepiness was not significantly different between the two drug conditions. The regions of diminished brain responses following D‐chlorpheniramine treatment were detected in the parietal, temporal and visual cortices, and in the cerebellum. The regions of augmented rCBF responses were found in the orbitofrontal cortex and cerebellar vermis. Conclusion These results suggest that D‐chlorpheniramine tends to suppress visuo‐spatial cognition and visuo‐motor coordinating functions rather than attention and motor functions during car driving. Copyright © 2008 John Wiley & Sons, Ltd. The sedative side effects of antihistamines have been recognized to be potentially dangerous in car driving, but the mechanism underlying these effects has not yet been elucidated to date. The aim of the present study is to examine regional cerebral blood flow (rCBF) responses during a simulated car-driving task following oral administration of D-chlorpheniramine using positron emission tomography (PET) and [15O]H2O, based on a single-blind cross-over study-design. Right-handed, healthy male volunteers (n = 14) drove a car in a simulated environment following oral administration of D-chlorpheniramine repetab 6 mg or placebo. Their rCBF was measured using PET with [15O]H2O in the following three conditions: (1) resting, (2) active driving, and (3) passive driving. All 'in-car' views during the simulated driving were videotaped and used for rating driving performance. Performance evaluation revealed that the number of lane deviations significantly increased in the D-chlorpheniramine condition compared with the placebo condition (p < 0.01). Subjective sleepiness was not significantly different between the two drug conditions. The regions of diminished brain responses following D-chlorpheniramine treatment were detected in the parietal, temporal and visual cortices, and in the cerebellum. The regions of augmented rCBF responses were found in the orbitofrontal cortex and cerebellar vermis. These results suggest that D-chlorpheniramine tends to suppress visuo-spatial cognition and visuo-motor coordinating functions rather than attention and motor functions during car driving. The sedative side effects of antihistamines have been recognized to be potentially dangerous in car driving, but the mechanism underlying these effects has not yet been elucidated to date. The aim of the present study is to examine regional cerebral blood flow (rCBF) responses during a simulated car-driving task following oral administration of D-chlorpheniramine using positron emission tomography (PET) and [15O]H2O, based on a single-blind cross-over study-design.OBJECTIVESThe sedative side effects of antihistamines have been recognized to be potentially dangerous in car driving, but the mechanism underlying these effects has not yet been elucidated to date. The aim of the present study is to examine regional cerebral blood flow (rCBF) responses during a simulated car-driving task following oral administration of D-chlorpheniramine using positron emission tomography (PET) and [15O]H2O, based on a single-blind cross-over study-design.Right-handed, healthy male volunteers (n = 14) drove a car in a simulated environment following oral administration of D-chlorpheniramine repetab 6 mg or placebo. Their rCBF was measured using PET with [15O]H2O in the following three conditions: (1) resting, (2) active driving, and (3) passive driving. All 'in-car' views during the simulated driving were videotaped and used for rating driving performance.METHODSRight-handed, healthy male volunteers (n = 14) drove a car in a simulated environment following oral administration of D-chlorpheniramine repetab 6 mg or placebo. Their rCBF was measured using PET with [15O]H2O in the following three conditions: (1) resting, (2) active driving, and (3) passive driving. All 'in-car' views during the simulated driving were videotaped and used for rating driving performance.Performance evaluation revealed that the number of lane deviations significantly increased in the D-chlorpheniramine condition compared with the placebo condition (p < 0.01). Subjective sleepiness was not significantly different between the two drug conditions. The regions of diminished brain responses following D-chlorpheniramine treatment were detected in the parietal, temporal and visual cortices, and in the cerebellum. The regions of augmented rCBF responses were found in the orbitofrontal cortex and cerebellar vermis.RESULTSPerformance evaluation revealed that the number of lane deviations significantly increased in the D-chlorpheniramine condition compared with the placebo condition (p < 0.01). Subjective sleepiness was not significantly different between the two drug conditions. The regions of diminished brain responses following D-chlorpheniramine treatment were detected in the parietal, temporal and visual cortices, and in the cerebellum. The regions of augmented rCBF responses were found in the orbitofrontal cortex and cerebellar vermis.These results suggest that D-chlorpheniramine tends to suppress visuo-spatial cognition and visuo-motor coordinating functions rather than attention and motor functions during car driving.CONCLUSIONThese results suggest that D-chlorpheniramine tends to suppress visuo-spatial cognition and visuo-motor coordinating functions rather than attention and motor functions during car driving.
Author	Tashiro, Manabu Okamura, Nobuyuki Yanai, Kazuhiko Mochizuki, Hideki Arai, Hiroyuki Itoh, Masatoshi Sakurada, Yumiko Horikawa, Etsuo Watanuki, Shoichi Maruyama, Masahiro
Author_xml	– sequence: 1 givenname: Manabu surname: Tashiro fullname: Tashiro, Manabu email: mtashiro@mail.tains.tohoku.ac.jp organization: Department of Pharmacology, Tohoku University Graduate School of Medicine, Sendai, Japan – sequence: 2 givenname: Yumiko surname: Sakurada fullname: Sakurada, Yumiko organization: Department of Pharmacology, Tohoku University Graduate School of Medicine, Sendai, Japan – sequence: 3 givenname: Hideki surname: Mochizuki fullname: Mochizuki, Hideki organization: Department of Pharmacology, Tohoku University Graduate School of Medicine, Sendai, Japan – sequence: 4 givenname: Etsuo surname: Horikawa fullname: Horikawa, Etsuo organization: Department of Geriatrics and Gerontology, Tohoku University Graduate School of Medicine, Sendai, Japan – sequence: 5 givenname: Masahiro surname: Maruyama fullname: Maruyama, Masahiro organization: Department of Geriatrics and Gerontology, Tohoku University Graduate School of Medicine, Sendai, Japan – sequence: 6 givenname: Nobuyuki surname: Okamura fullname: Okamura, Nobuyuki organization: Department of Pharmacology, Tohoku University Graduate School of Medicine, Sendai, Japan – sequence: 7 givenname: Shoichi surname: Watanuki fullname: Watanuki, Shoichi organization: Division of Cyclotron Nuclear Medicine, Cyclotron and Radioisotope Centre, Tohoku University, Sendai, Japan – sequence: 8 givenname: Hiroyuki surname: Arai fullname: Arai, Hiroyuki organization: Department of Geriatrics and Gerontology, Tohoku University Graduate School of Medicine, Sendai, Japan – sequence: 9 givenname: Masatoshi surname: Itoh fullname: Itoh, Masatoshi organization: Division of Cyclotron Nuclear Medicine, Cyclotron and Radioisotope Centre, Tohoku University, Sendai, Japan – sequence: 10 givenname: Kazuhiko surname: Yanai fullname: Yanai, Kazuhiko organization: Department of Pharmacology, Tohoku University Graduate School of Medicine, Sendai, Japan
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Georg Thieme Verlag: Stuttgart, Germany. 2002; 16 2002; 17 1987; 2 2004; 29 1973; 10 2002; 53 1987; 6 2002; 159 2005; 20 2000; 132 2003; 352 1971; 9 2006; 20 2006; 61 2000; 15 2004; 36 2000; 129 2004; 34 2005; 30 1972; 180 1992; 42 1998; 121 2003; 169 2001; 12 1991; 104 2001; 52 1988 1979; 17 2003b; 25 2004; 44 1988; 19 2002; 72 1999; 29 1998 1995; 118 2002; 2 1994; 47 1995; 116 2003a; 18 1995; 2 2001; 63 1987; 59 1976; 4 2003; 33 1991; 6 2001; 154 2007; 113 2004; 92 1995; 49 1977; 4 2003; 25 1995; 346 2005; 58 Talairach J (e_1_2_1_39_1) 1988 e_1_2_1_20_1 e_1_2_1_41_1 e_1_2_1_24_1 e_1_2_1_45_1 e_1_2_1_22_1 e_1_2_1_43_1 e_1_2_1_28_1 e_1_2_1_49_1 e_1_2_1_26_1 e_1_2_1_47_1 Gengo FM (e_1_2_1_9_1) 1987; 59 e_1_2_1_31_1 e_1_2_1_54_1 e_1_2_1_8_1 e_1_2_1_6_1 e_1_2_1_12_1 e_1_2_1_35_1 e_1_2_1_50_1 e_1_2_1_4_1 e_1_2_1_10_1 e_1_2_1_33_1 e_1_2_1_52_1 e_1_2_1_2_1 e_1_2_1_16_1 e_1_2_1_14_1 e_1_2_1_37_1 e_1_2_1_18_1 Peets EA (e_1_2_1_25_1) 1972; 180 e_1_2_1_42_1 e_1_2_1_40_1 e_1_2_1_23_1 e_1_2_1_46_1 e_1_2_1_21_1 e_1_2_1_44_1 e_1_2_1_27_1 e_1_2_1_48_1 e_1_2_1_29_1 e_1_2_1_7_1 e_1_2_1_30_1 e_1_2_1_55_1 e_1_2_1_5_1 e_1_2_1_3_1 e_1_2_1_13_1 e_1_2_1_34_1 e_1_2_1_51_1 e_1_2_1_11_1 e_1_2_1_32_1 e_1_2_1_53_1 e_1_2_1_17_1 e_1_2_1_38_1 e_1_2_1_15_1 e_1_2_1_36_1 e_1_2_1_19_1
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Snippet	Objectives The sedative side effects of antihistamines have been recognized to be potentially dangerous in car driving, but the mechanism underlying these... The sedative side effects of antihistamines have been recognized to be potentially dangerous in car driving, but the mechanism underlying these effects has not...
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SubjectTerms	Administration, Oral Adult antihistamine Automobile Driving Brain - blood supply Brain - drug effects car driving cerebral blood flow Cerebrovascular Circulation - drug effects Chlorpheniramine - pharmacology Cross-Over Studies Functional Laterality Histamine H1 Antagonists - pharmacology Humans impaired performance Male PET Positron-Emission Tomography Psychomotor Performance - drug effects Space Perception - drug effects Videotape Recording Visual Perception - drug effects
Title	Effects of a sedative antihistamine, D-chlorpheniramine, on regional cerebral perfusion and performance during simulated car driving
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