Chemical molecular‐based approach to overcome multidrug resistance in cancer by targeting P‐glycoprotein (P‐gp)

• Published in: Medicinal research reviews Vol. 41; no. 1; pp. 525 - 555
• Main Authors: Zhang, Hang, Xu, Haiwei, Ashby, Charles R., Assaraf, Yehuda G., Chen, Zhe‐Sheng, Liu, Hong‐Min
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.01.2021
• Subjects: cancer; Cancer therapies; Chemotherapy; Drug resistance; Glycoproteins; mechanism of action; multidrug resistance (MDR); Multidrug resistant organisms; pharmacological characterization; P‐glycoprotein (P‐gp) inhibitors; structure‐activity relationship (SAR) studies; pharmacological characterization; P-glycoprotein (P-gp) inhibitors; mechanism of action; multidrug resistance (MDR); structure-activity relationship (SAR) studies; cancer; chemotherapy

Multidrug resistance (MDR) remains one of the major impediments for efficacious cancer chemotherapy. Increased efflux of multiple chemotherapeutic drugs by transmembrane ATP‐binding cassette (ABC) transporter superfamily is considered one of the primary causes for cancer MDR, in which the role of P‐...