Nrf2–ARE signaling in cellular protection: Mechanism of action and the regulatory mechanisms

• Published in: Journal of cellular physiology Vol. 235; no. 4; pp. 3119 - 3130
• Main Authors: Shaw, Pallab, Chattopadhyay, Ansuman
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.04.2020
• Subjects: Animals; Antioxidants; Antioxidants - pharmacology; Homeostasis; Homeostasis - drug effects; Humans; Metals; NF-E2-Related Factor 2 - metabolism; Nrf2; Oxidants; Oxidative stress; Oxidative Stress - drug effects; Oxidizing agents; Regulatory mechanisms (biology); ROS; Signal Transduction - drug effects; stress response; Toxicants; Transcription; xenobiotic metabolizing enzymes; stress response; Nrf2; oxidative stress; ROS; xenobiotic metabolizing enzymes

Oxidative stress is the increase in cellular oxidant concentration in comparison to antioxidant titer. Toxic insults and many other diseased conditions are mediated through the formation of such condition. Once the redox equilibrium is disrupted, the cellular antioxidant system functions to bring ba...