Discrimination of oral squamous cell carcinoma from oral lichen planus by salivary metabolomics

• Published in: Oral diseases Vol. 26; no. 1; pp. 35 - 42
• Main Authors: Ishikawa, Shigeo, Sugimoto, Masahiro, Edamatsu, Kaoru, Sugano, Ayako, Kitabatake, Kenichiro, Iino, Mitsuyoshi
• Format: Journal Article
• Language: English
• Published: Denmark Wiley Subscription Services, Inc 01.01.2020
• Subjects: Acetic acid; Adult; Aged; Aged, 80 and over; Capillary electrophoresis; Carcinoma, Squamous Cell - diagnosis; Ethanolamine; Female; Humans; Indoles; Lichen planus; Lichen Planus, Oral - diagnosis; Male; Mass spectroscopy; Metabolites; Metabolomics; Middle Aged; Mouth Neoplasms - diagnosis; Oral cancer; oral lichen planus; Oral squamous cell carcinoma; Saliva; Saliva - metabolism; screening; Squamous cell carcinoma; Surgery; saliva; screening; oral squamous cell carcinoma; oral lichen planus; metabolites

Objective This study was conducted to distinguish salivary metabolites in oral squamous cell carcinoma (OSCC) from those in oral lichen planus (OLP) to identify practical biomarkers for the discrimination of OSCC from OLP. Subjects and Methods Whole unstimulated saliva samples were collected from pa...