Application of the Amyloid/Tau/Neurodegeneration Framework in Cognitively Intact Adults: The CABLE Study

• Published in: Annals of neurology Vol. 92; no. 3; pp. 439 - 450
• Main Authors: Hu, Hao, Bi, Yan‐Lin, Shen, Xue‐Ning, Ma, Ya‐Hui, Ou, Ya‐Nan, Zhang, Wei, Ma, Ling‐Zhi, Hu, He‐Ying, Dong, Qiang, Tan, Lan, Yu, Jin‐Tai
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.09.2022; Wiley Subscription Services, Inc
• Subjects: Alzheimer's disease; Amyloid; Biomarkers; Cerebrospinal fluid; Hypertension; Neurodegeneration; Neurodegenerative diseases; Population; Population studies; Probabilistic models; Risk analysis; Risk factors; Signs and symptoms; Social interactions; Tau protein; Thyroid; Thyroid diseases

Objectives The amyloid/tau/neurodegeneration (AT[N]) framework has conceptualized the Alzheimer's disease (AD) continuum as a continuum of disease with evidence of amyloid‐related pathologies independent of clinical manifestation. Based on this framework, it is necessary to reveal the distribut...