Role of inflammation in the pathogenesis of schizophrenia: A review of the evidence, proposed mechanisms and implications for treatment

• Published in: Early intervention in psychiatry Vol. 14; no. 4; pp. 385 - 397
• Main Authors: Mongan, David, Ramesar, Matthew, Föcking, Melanie, Cannon, Mary, Cotter, David
• Format: Journal Article
• Language: English
• Published: Melbourne Wiley Publishing Asia Pty Ltd 01.08.2020; Wiley Subscription Services, Inc
• Subjects: aetiology; Animals; Anti-Inflammatory Agents - therapeutic use; Biomarkers; Cytokines; Humans; immune system; Immunomodulation; Immunomodulators; Inflammation; Inflammation - drug therapy; Inflammation - immunology; Literature reviews; Pathogenesis; Schizophrenia; Schizophrenia - drug therapy; Schizophrenia - immunology; treatment; aetiology; immune system; treatment; schizophrenia; inflammation

Aim Over the past several decades, there has been a growing research interest in the role of inflammation in the pathogenesis of schizophrenia. This review aims to summarize evidence in support of this relationship, to discuss biological mechanisms that might explain it, and to explore the translati...