Receptor tyrosine kinase fusions act as a significant alternative driver of the serrated pathway in colorectal cancer development

• Published in: The Journal of pathology Vol. 251; no. 1; pp. 74 - 86
• Main Authors: Chan, Anthony W‐H, Pan, Yi, Tong, Joanna H‐M, Lung, Raymond W‐M, Kwan, Johnny S‐H, Chow, Chit, Tin, Edith K‐Y, Chung, Lau‐Ying, Li, Hui, Wong, Shela S‐Y, Chau, Shuk‐Ling, Chan, Yuk Yu, Mak, Tony W‐C, Ng, Simon Siu‐Man, To, Ka‐Fai
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.05.2020; Wiley Subscription Services, Inc
• Subjects: Cell fusion; Cell proliferation; Colorectal cancer; Colorectal carcinoma; Ectopic expression; fusion genes; Fusion protein; Genetic transformation; Kinases; Lesions; MAP kinase; p53 Protein; Polyps; Protein-tyrosine kinase receptors; receptor tyrosine kinase; Ret protein; serrated pathway; sessile serrated lesion; Translocation; Tumorigenesis; Tumors; fusion genes; sessile serrated lesion; receptor tyrosine kinase; colorectal cancer; serrated pathway

Serrated polyps are a clinically and molecularly heterogeneous group of lesions that can contribute to the development of colorectal cancers (CRCs). However, the molecular mechanism underlying the development of serrated lesions is still not well understood. Here, we combined multiple approaches to...